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6PPD-Q

Name: 6PPD-Q
Brand: TargetMol
SKU: T78474
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78474Cas No. 2754428-18-5

Alias 6PPD-Quinone

6PPD-Q (6PPD-Quinone) is an environmental pollutant that can target CNR2, CNR1, AA2AR, LCAT and TRPA1. Among them, CNR2 has the highest binding affinity and may act as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q can damage the sperm quality and induce the impairment of male reproductive ability in mice. 6PPD-Q can induce intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolytic metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation.

6PPD-Q

🥰Excellent

Purity: 99.40%

Catalog No. T78474Alias 6PPD-QuinoneCas No. 2754428-18-5

Pack Size	Price	Availability
1 mg	$55	In Stock
5 mg	$125	In Stock
10 mg	$183	In Stock
25 mg	$297	In Stock
50 mg	$453	In Stock

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Purity:99.40%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	6PPD-Q (6PPD-Quinone) is an environmental pollutant that can target CNR2, CNR1, AA2AR, LCAT and TRPA1. Among them, CNR2 has the highest binding affinity and may act as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q can damage the sperm quality and induce the impairment of male reproductive ability in mice. 6PPD-Q can induce intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolytic metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation.
Targets&IC50	ERRγ:6 nM, HEK293 cells (40 g/L HSA):23.96 μM, HEK293 cells (10% FBS):11.78 μM, HEK293 cells (Albumin-free):3.84 μM, L02 cells:22.51 µg/L
In vitro	METHODS: Mouse dopaminergic neurons were treated with 6PPD-Q (10 nM, 100 nM) for 48 hours to detect cell growth inhibition. RESULTS: R6PPD-Q did not exhibit significant cytotoxicity. [1] METHODS: Mouse dopaminergic neurons were treated with 6PPD-Q (10 nM, 100 nM) for 7 days, and target protein expression was detected by Western Blot. RESULTS: R6PPD-Q significantly increased Triton X-100-insoluble α-synuclein (α-syn) protein levels. [1]
In vivo	METHODS: To study the effect of 6PPD-Q on intestinal injury, 6PPD-Q (0.1, 1, 10, 100 μg/kg) was orally administered to ICR mice once daily for 21 days. RESULTS: 6PPD-Q caused intestinal injury in ICR mice, which was manifested as enhanced inflammatory response in jejunum and ileum and impaired intestinal barrier integrity. [2]
Synonyms	6PPD-Quinone

Chemical Properties

Molecular Weight	298.38
Formula	C₁₈H₂₂N₂O₂
Cas No.	2754428-18-5
Smiles	O=C1C=C(NC(C)CC(C)C)C(=O)C=C1NC=2C=CC=CC2

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (33.51 mM), Sonication and heating are recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3514 mL	16.7572 mL	33.5143 mL	167.5716 mL
5 mM	0.6703 mL	3.3514 mL	6.7029 mL	33.5143 mL
10 mM	0.3351 mL	1.6757 mL	3.3514 mL	16.7572 mL
20 mM	0.1676 mL	0.8379 mL	1.6757 mL	8.3786 mL

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

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For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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