Shopping Cart

Your shopping cart is currently empty

6PPD-Q

Name: 6PPD-Q
Brand: TargetMol
SKU: T78474
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Hot

Catalog No. T78474Cas No. 2754428-18-5

Alias 6PPD-Quinone

6PPD-Q (6PPD-Quinone) is an environmental pollutant that can target CNR2, CNR1, AA2AR, LCAT and TRPA1. Among them, CNR2 has the highest binding affinity and may act as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q can damage the sperm quality and induce the impairment of male reproductive ability in mice. 6PPD-Q can induce intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolytic metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation.

6PPD-Q

😃Good

Hot

Purity: 99.40%

Catalog No. T78474Alias 6PPD-QuinoneCas No. 2754428-18-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
5 mg	$125	In Stock	In Stock
10 mg	$183	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$453	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.40%

Appearance:Solid

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	6PPD-Q (6PPD-Quinone) is an environmental pollutant that can target CNR2, CNR1, AA2AR, LCAT and TRPA1. Among them, CNR2 has the highest binding affinity and may act as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q can damage the sperm quality and induce the impairment of male reproductive ability in mice. 6PPD-Q can induce intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolytic metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation.
Targets&IC50	L02 cells:22.51 µg/L, HEK293 cells (10% FBS):11.78 μM, HEK293 cells (40 g/L HSA):23.96 μM, HEK293 cells (Albumin-free):3.84 μM, ERRγ:6 nM
In vitro	METHODS: Mouse dopaminergic neurons were treated with 6PPD-Q (10 nM, 100 nM) for 48 hours to detect cell growth inhibition. RESULTS: R6PPD-Q did not exhibit significant cytotoxicity. [1] METHODS: Mouse dopaminergic neurons were treated with 6PPD-Q (10 nM, 100 nM) for 7 days, and target protein expression was detected by Western Blot. RESULTS: R6PPD-Q significantly increased Triton X-100-insoluble α-synuclein (α-syn) protein levels. [1]
In vivo	METHODS: To study the effect of 6PPD-Q on intestinal injury, 6PPD-Q (0.1, 1, 10, 100 μg/kg) was orally administered to ICR mice once daily for 21 days. RESULTS: 6PPD-Q caused intestinal injury in ICR mice, which was manifested as enhanced inflammatory response in jejunum and ileum and impaired intestinal barrier integrity. [2]
Synonyms	6PPD-Quinone

Chemical Properties

Molecular Weight	298.38
Formula	C₁₈H₂₂N₂O₂
Cas No.	2754428-18-5
Smiles	O=C1C=C(NC(C)CC(C)C)C(=O)C=C1NC=2C=CC=CC2

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (33.51 mM), Sonication and heating are recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3514 mL	16.7572 mL	33.5143 mL	167.5716 mL
5 mM	0.6703 mL	3.3514 mL	6.7029 mL	33.5143 mL
10 mM	0.3351 mL	1.6757 mL	3.3514 mL	16.7572 mL
20 mM	0.1676 mL	0.8379 mL	1.6757 mL	8.3786 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc