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Ro 67-7476

Name: Ro 67-7476
Brand: TargetMol
SKU: T3478
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3478Cas No. 298690-60-5

Ro 67-7476 is a positive allosteric modulator of mGluR1, which can enhance the calcium release induced by glutamate in HEK293 cells expressing rat mGluR1a. The EC50 is 60.1 nM. It is a P-ERK1/2 agonist, and can activate ERK1/2 phosphorylation without the addition of exogenous glutamate (EC50 = 163.3 nM).

Ro 67-7476

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Purity: 99.69%

Catalog No. T3478Cas No. 298690-60-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$43	In Stock	In Stock
5 mg	$85	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$271	In Stock	In Stock
50 mg	$490	In Stock	-
100 mg	$715	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$75	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Ro 67-7476 AI Summary

Ro 67-7476 exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in different cell lines. In Caco-2 cells, it shows a -3.11% inhibition at a concentration of 10 µM after 48 hours. It also demonstrates potential as a SARS-CoV-2 3CL-Pro protease inhibitor, with an inhibition percentage of 4.885% at 20µM. In VERO-6 cells, the compound inhibits virus-induced cytotoxicity by -0.25% under similar conditions. Additionally, Ro 67-7476 exhibits enzyme inhibitory activity, specifically inhibiting human HDAC6 activity by -30.68% with a commercial peptide substrate and 5.86% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ro 67-7476 is a positive allosteric modulator of mGluR1, which can enhance the calcium release induced by glutamate in HEK293 cells expressing rat mGluR1a. The EC50 is 60.1 nM. It is a P-ERK1/2 agonist, and can activate ERK1/2 phosphorylation without the addition of exogenous glutamate (EC50 = 163.3 nM).
Targets&IC50	mGluR1a:60.1 nM (EC50)

Chemical Properties

Molecular Weight	319.39
Formula	C₁₇H₁₈FNO₂S
Cas No.	298690-60-5
Smiles	Cc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1c1ccc(F)cc1
Relative Density.	1.268 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (156.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1310 mL	15.6548 mL	31.3097 mL	156.5484 mL
5 mM	0.6262 mL	3.1310 mL	6.2619 mL	31.3097 mL
10 mM	0.3131 mL	1.5655 mL	3.1310 mL	15.6548 mL
20 mM	0.1565 mL	0.7827 mL	1.5655 mL	7.8274 mL
50 mM	0.0626 mL	0.3131 mL	0.6262 mL	3.1310 mL
100 mM	0.0313 mL	0.1565 mL	0.3131 mL	1.5655 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc