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Ro 67-7476

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Catalog No. T3478Cas No. 298690-60-5

Ro 67-7476 is a positive allosteric modulator of mGluR1, which can enhance the calcium release induced by glutamate in HEK293 cells expressing rat mGluR1a. The EC50 is 60.1 nM. It is a P-ERK1/2 agonist, and can activate ERK1/2 phosphorylation without the addition of exogenous glutamate (EC50 = 163.3 nM).

Ro 67-7476

Ro 67-7476

😃Good
Purity: 99.69%
Catalog No. T3478Cas No. 298690-60-5
Ro 67-7476 is a positive allosteric modulator of mGluR1, which can enhance the calcium release induced by glutamate in HEK293 cells expressing rat mGluR1a. The EC50 is 60.1 nM. It is a P-ERK1/2 agonist, and can activate ERK1/2 phosphorylation without the addition of exogenous glutamate (EC50 = 163.3 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
2 mg$43In StockIn Stock
5 mg$85In StockIn Stock
10 mg$133In StockIn Stock
25 mg$271In StockIn Stock
50 mg$490In Stock-
100 mg$715InquiryInquiry
1 mL x 10 mM (in DMSO)$75In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.69%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Ro 67-7476 is a positive allosteric modulator of mGluR1, which can enhance the calcium release induced by glutamate in HEK293 cells expressing rat mGluR1a. The EC50 is 60.1 nM. It is a P-ERK1/2 agonist, and can activate ERK1/2 phosphorylation without the addition of exogenous glutamate (EC50 = 163.3 nM).
Targets&IC50
mGluR1a:60.1 nM (EC50)
Chemical Properties
Molecular Weight319.39
FormulaC17H18FNO2S
Cas No.298690-60-5
SmilesCc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1c1ccc(F)cc1
Relative Density.1.268 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (156.55 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1310 mL15.6548 mL31.3097 mL156.5484 mL
5 mM0.6262 mL3.1310 mL6.2619 mL31.3097 mL
10 mM0.3131 mL1.5655 mL3.1310 mL15.6548 mL
20 mM0.1565 mL0.7827 mL1.5655 mL7.8274 mL
50 mM0.0626 mL0.3131 mL0.6262 mL3.1310 mL
100 mM0.0313 mL0.1565 mL0.3131 mL1.5655 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

traumatic injuryRo 67-7476Ro 677476Ro 67 7476neuronal culturemGluR1mGluRMetabotropic glutamate receptorsInhibitorinhibitexcitatory postsynaptic potentialscAMP accumulation
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