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CYM 50769

Name: CYM 50769
Brand: TargetMol
SKU: T22702
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22702Cas No. 1421365-63-0

CYM 50769 is a neuropeptide W/B receptor 1 (NPBWR1, GPR7) antagonist(IC50 = 0.12 μM). CYM 50769 inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-targets with pharmaceutical relevance.

CYM 50769

🥰Excellent

Purity: 99.08%

Catalog No. T22702Cas No. 1421365-63-0

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$178	In Stock
25 mg	$397	In Stock
50 mg	$589	In Stock
100 mg	$843	In Stock

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Batch Information

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Purity:99.08%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CYM 50769 is a neuropeptide W/B receptor 1 (NPBWR1, GPR7) antagonist(IC50 = 0.12 μM). CYM 50769 inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-targets with pharmaceutical relevance.
Targets&IC50	NPBWR1:0.12 μM

Chemical Properties

Molecular Weight	416.86
Formula	C₂₄H₁₇ClN₂O₃
Cas No.	1421365-63-0
Smiles	COc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc34)c2=O)cc1
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (119.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3989 mL	11.9944 mL	23.9889 mL	119.9443 mL
5 mM	0.4798 mL	2.3989 mL	4.7978 mL	23.9889 mL
10 mM	0.2399 mL	1.1994 mL	2.3989 mL	11.9944 mL
20 mM	0.1199 mL	0.5997 mL	1.1994 mL	5.9972 mL
50 mM	0.0480 mL	0.2399 mL	0.4798 mL	2.3989 mL
100 mM	0.0240 mL	0.1199 mL	0.2399 mL	1.1994 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc