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Adriforant hydrochloride

Name: Adriforant hydrochloride
Brand: TargetMol
SKU: T12435
Rating: 4.5 (1 reviews)

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Catalog No. T12435Cas No. 2096455-90-0

Alias PF-3893787 hydrochloride

Adriforant hydrochloride is an antagonist of histamine H4 receptor.

Adriforant hydrochloride

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Catalog No. T12435Alias PF-3893787 hydrochlorideCas No. 2096455-90-0

Adriforant hydrochloride is an antagonist of histamine H4 receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	6-8 weeks	6-8 weeks
50 mg	Inquiry	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Adriforant hydrochloride is an antagonist of histamine H4 receptor.
Targets&IC50	H4 receptor bind:ki:2.4 nM , H4 receptor func:1.56 nM (ki)
In vitro	Adriforant in vitro IC50 on human native isolated eosinophils assessing actin polymerisation is 1.16 nM and assuming need 10 times the IC50 for >90% receptor occupancy (and therefore near complete inhibition of the response) suggested a concentration of 12 nM. The data in the whole blood GAFS assay demonstrates that the imetit induced shape change is completely blocked at a total blood concentration of 30 nM (which correcting for PPB and blood partitioning equates to approximately 10 nM free). For the purpose of dose projection and safety margin calculation, a Ceff/Cmin concentration of 10-15 nM is used
Synonyms	PF-3893787 hydrochloride

Chemical Properties

Molecular Weight	371.74
Formula	C₁₃H₂₅Cl₃N₆
Cas No.	2096455-90-0
Smiles	Cl.Cl.Cl.CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(N)n1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (224.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6901 mL	13.4503 mL	26.9005 mL	134.5026 mL
5 mM	0.5380 mL	2.6901 mL	5.3801 mL	26.9005 mL
10 mM	0.2690 mL	1.3450 mL	2.6901 mL	13.4503 mL
20 mM	0.1345 mL	0.6725 mL	1.3450 mL	6.7251 mL
50 mM	0.0538 mL	0.2690 mL	0.5380 mL	2.6901 mL
100 mM	0.0269 mL	0.1345 mL	0.2690 mL	1.3450 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc