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Isatin-β-thiosemicarbazone

Name: Isatin-β-thiosemicarbazone
Brand: TargetMol
SKU: T60272
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60272Cas No. 27830-79-1

Alias IBT

Isatin-β-thiosemicarbazone is a potent inhibitor of herpes simplex virus (HSV), exhibiting antiviral activity against both HSV-1 and HSV-2. Moreover, it is an effective anti-poxvirus agent for the treatment of monkeypox, orthopox, and cowpox viruses.

Isatin-β-thiosemicarbazone

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Purity: 99.51%

Catalog No. T60272Alias IBTCas No. 27830-79-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$70	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$172	In Stock	In Stock
50 mg	$255	In Stock	In Stock
100 mg	$413	-	In Stock
500 mg	$943	-	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.51%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Isatin-β-thiosemicarbazone is a potent inhibitor of herpes simplex virus (HSV), exhibiting antiviral activity against both HSV-1 and HSV-2. Moreover, it is an effective anti-poxvirus agent for the treatment of monkeypox, orthopox, and cowpox viruses.
In vitro	Isatin-beta-thiosemicarbazone (IBT) at a concentration of 14 muM inhibited the multiplication of vaccinia virus in HeLa cells. For the first 3 h after infection, viral deoxyribonucleic acid (DNA) was synthesized in the presence of IBT at the same rate as in the control culture.[2]
Synonyms	IBT

Chemical Properties

Molecular Weight	220.25
Formula	C₉H₈N₄OS
Cas No.	27830-79-1
Smiles	NC(=S)N\N=C1/C(=O)NC2=CC=CC=C12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (510.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (18.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5403 mL	22.7015 mL	45.4030 mL	227.0148 mL
5 mM	0.9081 mL	4.5403 mL	9.0806 mL	45.4030 mL
10 mM	0.4540 mL	2.2701 mL	4.5403 mL	22.7015 mL
20 mM	0.2270 mL	1.1351 mL	2.2701 mL	11.3507 mL
50 mM	0.0908 mL	0.4540 mL	0.9081 mL	4.5403 mL
100 mM	0.0454 mL	0.2270 mL	0.4540 mL	2.2701 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc