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Cinchonine
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Catalog No. T0012Cas No. 118-10-5
Alias LA40221, (8R,9S)-Cinchonine
Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.
Cinchonine
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Purity: 99.45%
Catalog No. T0012Alias LA40221, (8R,9S)-CinchonineCas No. 118-10-5
Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 g | $29 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.45%
Appearance:Solid
Color:White
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Product Introduction
Cinchonine AI Summary
Cinchonine exhibits multifaceted bioactivities, prominently displaying significant antimalarial properties against various strains of Plasmodium falciparum, including chloroquine-sensitive (3D7) and chloroquine-resistant (W2 and K1) strains, with low IC50 values ranging from 21.0 to 220.0 nM. The compound also inhibits parasite development in erythrocytes and heme polymerization in Plasmodium falciparum. It shows moderate cytotoxicity against human cell lines, including hepatocellular carcinoma (Huh7) and WI38 cells, with high selectivity indices. Additionally, Cinchonine exhibits potent inhibition of various targets including HIV1 reverse transcriptase, acetylcholinesterase, butyrylcholinesterase, SKCa channels, and cytochrome P450 2D6. It also demonstrates significant activity in antitrypanosomal, antileishmanial, lipid storage modulation, Nrf2 screening, and inhibition of microbial strains and SARS-CoV-2 viral activities..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia. |
| Targets&IC50 | P-gp: |
| Synonyms | LA40221, (8R,9S)-Cinchonine |
| Molecular Weight | 294.39 |
| Formula | C19H22N2O |
| Cas No. | 118-10-5 |
| Smiles | [C@@H](O)([C@@]1([N@@]2C[C@H](C=C)[C@](C1)(CC2)[H])[H])C=3C4=C(N=CC3)C=CC=C4 |
| Relative Density. | Ca. 130 kg/m3. |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.95 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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