SAH-SOS1A

Name: SAH-SOS1A
Brand: TargetMol
SKU: TP2116
Rating: 4.5 (1 reviews)

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Catalog No. TP2116Cas No. 1652561-87-9

KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

SAH-SOS1A

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Catalog No. TP2116Cas No. 1652561-87-9

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5 mg	$1,394	Backorder

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Product Introduction

Bioactivity

Description	KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.
Targets&IC50	KRas (Q61H):175 nM (EC50), KRas (G12C):140 nM (EC50), KRas (G12V):154 nM (EC50), KRas (WT):106 nM (EC50), KRas (G12S):155 nM (EC50), KRas (G12D):109 nM (EC50)

Chemical Properties

Molecular Weight	2187.53
Formula	C₁₀₀H₁₅₉N₂₇O₂₈
Cas No.	1652561-87-9
Relative Density.	1.42 g/cm3 (Predicted)
Sequence	Arg-Arg-Phe-Phe-Gly-Ile-{Aaa}-Leu-Thr-Asn-{Aaa}-Leu-Lys-Thr-Glu-Glu-Gly-Asn (Covalent bridge:Aaa7-Aaa11)
Sequence Short	RRFFGI{Aaa}LTN{Aaa}LKTEEGN (Covalent bridge:Aaa7-Aaa11)

Storage & Solubility Information

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O: 1 mg/mL (0.46 mM), Sonication is recommended.

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