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α-Cyclodextrin

Name: α-Cyclodextrin
Brand: TargetMol
SKU: T17303
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17303Cas No. 10016-20-3

Alias NSC-269470, NSC269470, NSC 269470, Alfadex

α-Cyclodextrin (Alfadex) is a soluble fiber derived from corn and has beneficial effects on weight management in obese individuals with type 2 diabetes.

α-Cyclodextrin

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Purity: 99.9%

Catalog No. T17303Alias NSC-269470, NSC269470, NSC 269470, AlfadexCas No. 10016-20-3

α-Cyclodextrin (Alfadex) is a soluble fiber derived from corn and has beneficial effects on weight management in obese individuals with type 2 diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$36	-	In Stock
5 g	$56	-	In Stock
10 g	$81	-	In Stock
25 g	$133	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	α-Cyclodextrin (Alfadex) is a soluble fiber derived from corn and has beneficial effects on weight management in obese individuals with type 2 diabetes.
In vivo	α-Cyclodextrin preferentially reduces blood levels of saturated and trans fats in the LDL receptor knockout mice[2]. Two independent in vivo biological test systems were used, a single cell Xenopus oocyte with expressed human aquaporin for cell hydration studies and the nematode Caenorhabditis elegans for testing life span in the treated animals. α-Cyclodextrin was found to enhance water uptake through aquaporins of oocytes. Furthermore, α-Cyclodextrin promoted longevity in C. elegans[3].
Synonyms	NSC-269470, NSC269470, NSC 269470, Alfadex

Chemical Properties

Molecular Weight	972.84
Formula	C₃₆H₆₀O₃₀
Cas No.	10016-20-3
Smiles	C(O)[C@@H]1[C@@]2([C@H](O)[C@@H](O)[C@](O1)(O[C@@]3([C@@H](CO)O[C@@]([C@H](O)[C@H]3O)(O[C@@]4([C@@H](CO)O[C@@]([C@H](O)[C@H]4O)(O[C@]5([C@H](O)[C@@H](O)[C@@](O[C@]6([C@H](O)[C@@H](O)[C@@](O[C@]7([C@H](O)[C@@H](O)[C@@](O2)(O[C@@H]7CO)[H])[H])(O[C@@H]6CO)[H])[H])(O[C@@H]5CO)[H])[H])[H])[H])[H])[H])[H])[H]
Relative Density.	1.483 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (41.12 mM), Sonication is recommended.

DMSO: 100 mg/mL (102.79 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0279 mL	5.1396 mL	10.2792 mL	51.3959 mL
5 mM	0.2056 mL	1.0279 mL	2.0558 mL	10.2792 mL
10 mM	0.1028 mL	0.5140 mL	1.0279 mL	5.1396 mL
20 mM	0.0514 mL	0.2570 mL	0.5140 mL	2.5698 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0206 mL	0.1028 mL	0.2056 mL	1.0279 mL
100 mM	0.0103 mL	0.0514 mL	0.1028 mL	0.5140 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc