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GPR84 antagonist 8 is a selective GPR84 antagonist applicable for investigating inflammatory and fibrotic diseases.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $74 | - | In Stock | |
| 5 mg | $181 | - | In Stock | |
| 10 mg | $289 | - | In Stock | |
| 25 mg | $579 | - | In Stock | |
| 50 mg | $993 | - | In Stock |
| Description | GPR84 antagonist 8 is a selective GPR84 antagonist applicable for investigating inflammatory and fibrotic diseases. |
| In vitro | GPR84 antagonist 8 (10μM, 30 minutes) was used to treat lipopolysaccharide (LPS)-pretreated bone marrow-derived macrophages (BMDMs), followed by the addition of 1μM 6-OAU. Western blot analysis Results indicated that GPR84 antagonist 8 could partially block 6-OAU-induced phosphorylation of AKT and ERK proteins. [1] |
| Molecular Weight | 421.45 |
| Formula | C23H23N3O5 |
| Cas No. | 1445846-30-9 |
| Smiles | O=C1N=C(OCC2OCCOC2)C=C3C=4C=CC(OCC5=NC=CC=C5)=CC4CCN13 |
| Relative Density. | 1.38 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (9.49 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
| ||||||||||||||||
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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