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NNC 55-0396

Name: NNC 55-0396
Brand: TargetMol
SKU: T12238
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12238Cas No. 357400-13-6

Alias NNC 55-0396 dihydrochloride

NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC50 of 6.8 μM, used in studies to prevent human ovarian cancer cell proliferation.

NNC 55-0396

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Purity: 99.00%

Catalog No. T12238Alias NNC 55-0396 dihydrochlorideCas No. 357400-13-6

NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC50 of 6.8 μM, used in studies to prevent human ovarian cancer cell proliferation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$60	In Stock	In Stock
5 mg	$128	In Stock	In Stock
10 mg	$213	In Stock	In Stock
25 mg	$373	In Stock	In Stock
50 mg	$578	In Stock	In Stock
100 mg	$828	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.00%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

NNC 55-0396 AI Summary

NNC 55-0396 exhibits a broad spectrum of bioactivities, including inhibitory effects on various enzymes and virus interactions. It is known to inhibit genomic imprint erasure, tau fibril formation, ROR gamma transcriptional activity, ALDH1A1, Bacillus subtilis Sfp PPTase, Menin-MLL interaction in MLL-related leukemias, Fructose-1,6-bisphosphate aldolase from Giardia Lamblia, N370S glucocerebrosidase, histone lysine methyltransferase G9a, 15-human lipoxygenase 2, human flap endonuclease 1 (FEN1), TGF-b, polymerase kappa, human tyrosyl-DNA phosphodiesterase 1 (TDP1), alpha-synuclein, Stage-Specific Inhibitors of Vaccinia Orthopoxvirus, and inhibiting the binding or entry into cells by Lassa Virus and Marburg Virus. In terms of calcium channel inhibition, NNC 55-0396 inhibits Cav2.2 in human SH-SY5Y cells with an IC50 of 7000.0 nM and Cav3.2-alpha1 in HEK293T cells with an IC50 of 2000.0 nM. The compound also displays antiviral properties. Specifically, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 μM concentration after 48 hours, with an 11.35% inhibition rate. It has an IC50 value of 8210.0 nM against SARS-CoV-2 in VERO-E6 cells and an inhibition rate of -1.739% at 20 μM concentration against the SARS-CoV-2 3CL-Pro protease. The high selectivity index of 0.99 against SARS-CoV-2 highlights its specificity with low toxicity in VERO-E6 cells. Finally, NNC 55-0396 demonstrates inhibitory activity against human HDAC6 enzyme, with inhibition percentages of 15.09% using a commercial peptide substrate and -3.03% with a custom peptide substrate, suggesting variability depending on the substrate used..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC50 of 6.8 μM, used in studies to prevent human ovarian cancer cell proliferation.
Synonyms	NNC 55-0396 dihydrochloride

Chemical Properties

Molecular Weight	564.56
Formula	C₃₀H₄₀Cl₂FN₃O₂
Cas No.	357400-13-6
Smiles	Cl.Cl.CC(C)C1c2ccc(F)cc2CCC1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C1CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (265.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7713 mL	8.8565 mL	17.7129 mL	88.5645 mL
5 mM	0.3543 mL	1.7713 mL	3.5426 mL	17.7129 mL
10 mM	0.1771 mL	0.8856 mL	1.7713 mL	8.8565 mL
20 mM	0.0886 mL	0.4428 mL	0.8856 mL	4.4282 mL
50 mM	0.0354 mL	0.1771 mL	0.3543 mL	1.7713 mL
100 mM	0.0177 mL	0.0886 mL	0.1771 mL	0.8856 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc