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BAY-091

Name: BAY-091
Brand: TargetMol
SKU: T60147
Price: 912 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60147Cas No. 2922280-34-8

BAY-091 is a novel, potent, and highly selective inhibitor of PIP4K2A kinase.

BAY-091

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Purity: 99.23%

Catalog No. T60147Cas No. 2922280-34-8

BAY-091 is a novel, potent, and highly selective inhibitor of PIP4K2A kinase.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$75	In Stock	In Stock
5 mg	$187	In Stock	In Stock
10 mg	$298	In Stock	In Stock
25 mg	$475	In Stock	In Stock
50 mg	$678	In Stock	In Stock
100 mg	$912	-	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.23%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

BAY-091 AI Summary

BAY-091 exhibits selective bioactivity as an inhibitor of the PIP4K2A enzyme, with its potency varying across different cell types and assays. In sf21 cells, it strongly inhibits PIP4K2A activity with IC50 values ranging from 1.0 nM to 16.0 nM. However, in human THP-1 cells, its potency drops significantly, demonstrating an IC50 greater than 50,000 nM, and binding affinity with EC50 values of 1100.0 nM and 1800.0 nM in distinct assays. The compound also displays metabolic stability in rat and human liver microsomes and hepatocytes, and moderate permeability in Caco-2 cells and the PAMPA assay. Its impact on CYP enzymes is limited, and it does not exhibit significant antiproliferative activity against various cell lines. In terms of effects on different cell types, BAY-091 shows variability in growth rates: 0.67 to 0.98 in HEK293T cells, 0.1 to 0.91 in U2OS cells, and 0.65 to 0.93 in human fibroblast cells, hinting at its differential impact on cell viability and proliferation. Additionally, the compound affects the thermal stability of protein domains, generally decreasing the melting temperature (TM) of most domains, with a notable increase in TM observed in the domain spanning residues E122 to S403, which suggests potential stabilization in that region..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

BAY-091 is a novel, potent, and highly selective inhibitor of PIP4K2A kinase.

Chemical Properties

Molecular Weight	440.47
Formula	C₂₆H₂₁FN₄O₂
Cas No.	2922280-34-8
Smiles	N([C@@H](C(O)=O)CC)C=1C2=C(N=C(C1C#N)C3=CC=C(C=C3)C4=C(F)C(C)=CC=C4)C=NC=C2
Relative Density.	1.35 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (255.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2703 mL	11.3515 mL	22.7030 mL	113.5151 mL
5 mM	0.4541 mL	2.2703 mL	4.5406 mL	22.7030 mL
10 mM	0.2270 mL	1.1352 mL	2.2703 mL	11.3515 mL
20 mM	0.1135 mL	0.5676 mL	1.1352 mL	5.6758 mL
50 mM	0.0454 mL	0.2270 mL	0.4541 mL	2.2703 mL
100 mM	0.0227 mL	0.1135 mL	0.2270 mL	1.1352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc