keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OSK-1 is a potent potassium channel blocker belonging to the α-KTx3 toxins. It exhibits IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3 channels, respectively. Additionally, OSK-1 acts as a moderate blocker of the calcium-activated KCa3.1 channel, with an IC50 of 225 nM. Consequently, OSK-1 finds application as an immunosuppressive drug.
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25 mg | Inquiry | $ 1,520.00 |
Description | OSK-1 is a potent potassium channel blocker belonging to the α-KTx3 toxins. It exhibits IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3 channels, respectively. Additionally, OSK-1 acts as a moderate blocker of the calcium-activated KCa3.1 channel, with an IC50 of 225 nM. Consequently, OSK-1 finds application as an immunosuppressive drug. |
Targets&IC50 | Kv1.2:5.4 nM (IC50), KCa3.1:225 nM (IC50), Kv1.1:0.6 nM (IC50), Kv1.3:0.014 nM (IC50) |
In vitro | OSK1 does not influence the K Ca 2.1, K Ca 2.2, K Ca 2.3, and K Ca 1.1 channels at micromolar concentrations, but exhibits moderate activity on the K Ca 3.1 channel (also known as IK1 or SK4), with an IC50 value of 225 nM[1]. |
In vivo | OSK1, when administered through intracerebroventricular injection, is lethal to mice, exhibiting a 50% lethal dose (LD 50) value of 2 μg/kg[1]. |
Molecular Weight | N/A |
CAS No. | 183815-75-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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OSK-1 183815-75-0 OSK 1 OSK1 inhibitor inhibit