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5-HT1AR agonist 1
🥰Excellent
Catalog No. T210359
5-HT1AR agonist 1 (Compound A3) displays a relatively balanced multi-target activity profile, including 5-HT1AR agonist (EC50= 34 nM), SERT reuptake inhibitor (IC50= 12 nM), NET reuptake inhibitor (IC50= 78 nM), and DAT reuptake inhibitor (IC50= 135 nM). It demonstrates significant antidepressant effects, excellent bioavailability, and low clearance, making it a promising candidate for research in the field of antidepressant drugs^.
5-HT1AR agonist 1
5-HT1AR agonist 1
🥰Excellent
Catalog No. T210359
5-HT1AR agonist 1 (Compound A3) displays a relatively balanced multi-target activity profile, including 5-HT1AR agonist (EC50= 34 nM), SERT reuptake inhibitor (IC50= 12 nM), NET reuptake inhibitor (IC50= 78 nM), and DAT reuptake inhibitor (IC50= 135 nM). It demonstrates significant antidepressant effects, excellent bioavailability, and low clearance, making it a promising candidate for research in the field of antidepressant drugs^.
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Product Introduction
Bioactivity
Chemical Properties
| Description | 5-HT1AR agonist 1 (Compound A3) displays a relatively balanced multi-target activity profile, including 5-HT1AR agonist (EC50= 34 nM), SERT reuptake inhibitor (IC50= 12 nM), NET reuptake inhibitor (IC50= 78 nM), and DAT reuptake inhibitor (IC50= 135 nM). It demonstrates significant antidepressant effects, excellent bioavailability, and low clearance, making it a promising candidate for research in the field of antidepressant drugs^. |
| Targets&IC50 | DAT:135 nM, NET:78 nM, SERT:12 nM |
| In vivo | The 5-HT1AR agonist 1 (2.5 MG/KG, I.V. and 10 MG/KG, P.O.) exhibits excellent oral bioavailability and low clearance in mice. In the forced swim test, 5-HT1AR agonist 1 (30 MG/KG, i.p., 30 min) demonstrates significant antidepressant potential in mice, comparable to the effects of Vilazodone. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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