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ARDP0006
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Catalog No. T19900Cas No. 81-55-0
ARDP0006 is an inhibitor of NS2B-NS3 protease.
ARDP0006
Copy Product Info🥰Excellent
Purity: 99.01%
Catalog No. T19900Cas No. 81-55-0
ARDP0006 is an inhibitor of NS2B-NS3 protease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.01%
Appearance:Solid
Color:Red
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Product Introduction
ARDP0006 AI Summary
ARDP0006 exhibits a broad spectrum of bioactivities, including cytotoxic effects on various cell lines and modulation of metabolic activity and viability as shown by Cell Viability assays. It demonstrates significant potency in inducing hypoxia response, erasure of genomic imprints, and impacts specific signaling pathways such as NF-kB, p53, TNF-alpha secretion, antioxidant response element (ARE), and various nuclear receptors. The compound has potential inhibitory effects on HPGD and APE1 enzymes. In antiviral studies, ARDP0006 shows activity against Dengue viruses 1, 2, 3, and 4 with the highest potency against Dengue virus 2 (EC50 = 440.0 nM) and Chikungunya virus, reducing viral loads effectively in human cell lines. It inhibits NS2B-NS3 protease activity and intramolecular cleavage in DENV2 with an EC50 of 4200.0 nM and displays cytotoxicity in monkey LLC-MK2 cells (CC50 = 69,400.0 nM). Additionally, it demonstrates high permeability at pH 7.4 and significant antiviral activity in human Huh-7 and K562 cells infected with DENV2, achieving a log reduction of viral titer greater than 1.0 PFU/ml at 1 uM after 72 hours. The compound also exhibits inhibition of DENV2 protease with Ki values of 432,000.0 nM and 4200.0 nM using different substrates..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ARDP0006 is an inhibitor of NS2B-NS3 protease. |
| Molecular Weight | 330.21 |
| Formula | C14H6N2O8 |
| Cas No. | 81-55-0 |
| Smiles | Oc1ccc(c2C(=O)c3c(ccc(O)c3C(=O)c12)[N+]([O-])=O)[N+]([O-])=O |
| Relative Density. | 1.4944 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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