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PHA 568487 free base

Name: PHA 568487 free base
Brand: TargetMol
SKU: T23146
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23146Cas No. 527680-56-4

Alias PHA 568487

The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.

PHA 568487 free base

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Purity: 99.74%

Catalog No. T23146Alias PHA 568487Cas No. 527680-56-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$37	In Stock	In Stock
25 mg	$68	In Stock	In Stock
50 mg	$132	In Stock	In Stock
100 mg	$237	In Stock	In Stock
200 mg	$331	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.74%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

PHA 568487 free base AI Summary

PHA 568487 free base exhibits potent agonist activity at the rat alpha7 nicotinic acetylcholine receptor (nAChR) expressed in GH4C1 cells, with an EC50 value of 36.2 nM and an Emax value of 96.0% relative to nicotine. It also demonstrates antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells, showing varying inhibition rates and concentrations. Specifically, it inhibited SARS-CoV-2 cytotoxicity at 10 µM after 48 hours, with inhibition percentages of -3.54% in Caco-2 cells and -0.04% in VERO-6 cells. Additionally, PHA 568487 free base moderately inhibits the SARS-CoV-2 3CL-Pro protease by approximately 9.983% at a concentration of 20 µM. Furthermore, it shows inhibitory activity against human HDAC6, with greater efficacy observed using a commercial peptide substrate compared to a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.
Synonyms	PHA 568487

Chemical Properties

Molecular Weight	288.34
Formula	C₁₆H₂₀N₂O₃
Cas No.	527680-56-4
Smiles	O=C(N[C@H]1CN2CCC1CC2)c1ccc2OCCOc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (104.04 mM), Sonication is recommended.

H2O: < 40.44 mg/mL (100 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4681 mL	17.3406 mL	34.6813 mL	173.4064 mL
5 mM	0.6936 mL	3.4681 mL	6.9363 mL	34.6813 mL
10 mM	0.3468 mL	1.7341 mL	3.4681 mL	17.3406 mL
20 mM	0.1734 mL	0.8670 mL	1.7341 mL	8.6703 mL
50 mM	0.0694 mL	0.3468 mL	0.6936 mL	3.4681 mL
100 mM	0.0347 mL	0.1734 mL	0.3468 mL	1.7341 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc