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Salicyluric acid

Name: Salicyluric acid
Brand: TargetMol
SKU: T5221
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5221Cas No. 487-54-7

Alias N-Salicyloylglycine, N-(2-Hydroxybenzoyl)glycine, 2-Hydroxy Hippuric Acid

Salicyluric acid (2-Hydroxy Hippuric Acid) is a metabolite of Salicylic Acid.

Salicyluric acid

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Purity: 99.70%

Catalog No. T5221Alias N-Salicyloylglycine, N-(2-Hydroxybenzoyl)glycine, 2-Hydroxy Hippuric AcidCas No. 487-54-7

Salicyluric acid (2-Hydroxy Hippuric Acid) is a metabolite of Salicylic Acid.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$38	In Stock	In Stock
500 mg	$64	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.70%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Salicyluric acid AI Summary

Salicyluric acid demonstrates inhibition of integrase activity in vitro, showing 28.9% and 33.3% inhibition in the 3''-processing method and 25.0% and 33.3% inhibition in the strand transfer method. It has a log relative capacity factor (k') of -0.68 in HPLC artificial membrane chromatography and alters the mean peak APTT value in rats to 28.0 at a dose of 50 mg/kg. This compound stimulates oxygen consumption in rat recombinant peptidylglycine alpha-amidating monooxygenase, with a Km of 860,000 nM, a Vmax of 4.9 /s, and a Vmax/Km ratio of 7.1 x 10^-3 /M/s, showing an activity ratio of 1.1 compared to hippuric acid. In the HTRF assay, it inhibits PHD1 with an IC50 value exceeding 1,000,000 nM. It also exhibits potency in inhibiting HSD17B4 at 3162.3 nM, Anthrax Lethal Toxin Internalization at 3981.1 nM, and HPGD at 3548.1 nM. In the Cytochrome panel assay, it has an AC50 of 5011.87 nM and shows a GI50 of 100,000 nM in various human tumor cell lines, including MDA-N Breast, SN12C Renal, and NCI-H23 Non-Small Cell Lung. Additionally, Salicyluric acid inhibits rat Oat1 in Xenopus oocytes with a Ki of 11,000 nM, and PAH uptake in OAT-expressing OK cells with an IC50 of 27,000 nM, serving as a transporter inhibitor. It shows a retention time of 18.6 minutes in C57BL/6J mouse intestine content and urine treated with RAH at 200 mg/kg, indicating an interaction with these biological samples..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Salicyluric acid (2-Hydroxy Hippuric Acid) is a metabolite of Salicylic Acid.
Synonyms	N-Salicyloylglycine, N-(2-Hydroxybenzoyl)glycine, 2-Hydroxy Hippuric Acid

Chemical Properties

Molecular Weight	195.17
Formula	C₉H₉NO₄
Cas No.	487-54-7
Smiles	OC(=O)CNC(=O)C1=C(O)C=CC=C1
Relative Density.	1.401 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (51.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1237 mL	25.6187 mL	51.2374 mL	256.1869 mL
5 mM	1.0247 mL	5.1237 mL	10.2475 mL	51.2374 mL
10 mM	0.5124 mL	2.5619 mL	5.1237 mL	25.6187 mL
20 mM	0.2562 mL	1.2809 mL	2.5619 mL	12.8093 mL
50 mM	0.1025 mL	0.5124 mL	1.0247 mL	5.1237 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc