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Pinacidil

Name: Pinacidil
Brand: TargetMol
SKU: T12478L
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12478LCas No. 60560-33-0

Alias S-1230, S 1230, P-1134, P1134, P 1134

Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.

Pinacidil

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Purity: 99.9%

Catalog No. T12478LAlias S-1230, S 1230, P-1134, P1134, P 1134Cas No. 60560-33-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$97	In Stock	In Stock
50 mg	$165	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.9%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Pinacidil AI Summary

Pinacidil exhibits a range of bioactivities relating to muscle relaxation, insulin secretion, and cardiovascular effects. It has potent vasorelaxant properties, with an EC50 of 724.44 nM and high intrinsic activity of 91.9% in relaxing rat aorta precontracted with KCl. Additionally, it inhibits the contraction of rat detrusor strips with an IC50 of 630.0 nM and demonstrates significant relaxant activities in various smooth muscles, including the rat aorta and guinea pig trachea. In terms of insulin secretion, Pinacidil inhibits glucose-stimulated insulin release from rat islets, with an IC50 value greater than 100,000 nM. It also demonstrates inhibitory activity in specific cellular assays, such as inhibiting ATP-dependent taurocholate uptake in human BSEP with an IC50 of 348,100 nM. Pinacidil shows antihypertensive effects in animal models, including significant reductions in blood pressure in spontaneously hypertensive rats and hypertensive dogs. It demonstrates efficacy in various vasorelaxant and potassium channel activities, suggesting potential therapeutic benefits in cardiovascular treatments. Additionally, the compound exhibits selective bioactivities related to its interaction with potassium channels, showing a significant effect on ATP-sensitive potassium channels (KATP) in different smooth muscle and pancreatic islet cells. Overall, Pinacidil presents a promising profile as a vasorelaxant and antihypertensive agent, while also affecting glucose-induced insulin secretion and demonstrating significant interaction with potassium channels..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.
Synonyms	S-1230, S 1230, P-1134, P1134, P 1134

Chemical Properties

Molecular Weight	245.32
Formula	C₁₃H₁₉N₅
Cas No.	60560-33-0
Smiles	CC(N\C(Nc1ccncc1)=N/C#N)C(C)(C)C
Relative Density.	1.1402 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (407.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0763 mL	20.3815 mL	40.7631 mL	203.8154 mL
5 mM	0.8153 mL	4.0763 mL	8.1526 mL	40.7631 mL
10 mM	0.4076 mL	2.0382 mL	4.0763 mL	20.3815 mL
20 mM	0.2038 mL	1.0191 mL	2.0382 mL	10.1908 mL
50 mM	0.0815 mL	0.4076 mL	0.8153 mL	4.0763 mL
100 mM	0.0408 mL	0.2038 mL	0.4076 mL	2.0382 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc