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Acamprosate calcium

Name: Acamprosate calcium
Brand: TargetMol
SKU: T1673
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1673Cas No. 77337-73-6

Alias Sobriol, N-Acetylhomotaurine Calcium, Campral EC, Calcium N-acetylhomotaurinate, calcium acetylhomotaurinate, Alcomed

Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems, used for treating alcohol dependence.

Acamprosate calcium

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Purity: 99.93%

Catalog No. T1673Alias Sobriol, N-Acetylhomotaurine Calcium, Campral EC, Calcium N-acetylhomotaurinate, calcium acetylhomotaurinate, AlcomedCas No. 77337-73-6

Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems, used for treating alcohol dependence.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$40	In Stock	In Stock
1 mL x 10 mM (in H2O)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:solid

Color:White

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COA LCMS HNMR

Product Introduction

Acamprosate calcium AI Summary

Acamprosate calcium demonstrates bioactivity in inhibiting the entry of the Ebola virus with AC50 values ranging from 1258.9 nM to 1.259 µM based on qHTS assay results. However, it exhibits low bioactivity against SARS-CoV-2, evidenced by an inhibition index of 0.09644 in Vero E6 cells. At a 10 µM concentration, Acamprosate calcium shows minimal inhibition (5.46%) of SARS-CoV-2-induced cytotoxicity in Caco-2 cells after 48 hours. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 11.42% at a 20 µM concentration, as measured by FRET response. Despite its antiviral properties, the compound exhibited a negligible inhibition (-0.15%) of cytotoxicity in VERO-6 cells exposed to SARS-CoV-2 at a 10 µM concentration over a 48-hour period..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems, used for treating alcohol dependence.
Synonyms	Sobriol, N-Acetylhomotaurine Calcium, Campral EC, Calcium N-acetylhomotaurinate, calcium acetylhomotaurinate, Alcomed

Chemical Properties

Molecular Weight	400.48
Formula	C₁₀H₂₀CaN₂O₈S₂
Cas No.	77337-73-6
Smiles	[Ca+2].CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 240 mg/mL (599.28 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.4970 mL	12.4850 mL	24.9700 mL	124.8502 mL
5 mM	0.4994 mL	2.4970 mL	4.9940 mL	24.9700 mL
10 mM	0.2497 mL	1.2485 mL	2.4970 mL	12.4850 mL
20 mM	0.1249 mL	0.6243 mL	1.2485 mL	6.2425 mL
50 mM	0.0499 mL	0.2497 mL	0.4994 mL	2.4970 mL
100 mM	0.0250 mL	0.1249 mL	0.2497 mL	1.2485 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc