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LSD1/HDAC6-IN-2

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Catalog No. T89134Cas No. 2982787-50-6

LSD1/HDAC6-IN-2 (JBI-802) is an orally active inhibitor of LSD1/HDAC6/HDAC8 with IC₅₀ values of 50 nM, 11 nM, and 98 nM respectively, exhibiting good selectivity towards MAOs. JBI-802 demonstrates antiproliferative activity against multiple cell lines including AML, CLL, and SCLC, inhibiting tumour growth.

LSD1/HDAC6-IN-2

LSD1/HDAC6-IN-2

😃Good
Catalog No. T89134Cas No. 2982787-50-6
LSD1/HDAC6-IN-2 (JBI-802) is an orally active inhibitor of LSD1/HDAC6/HDAC8 with IC₅₀ values of 50 nM, 11 nM, and 98 nM respectively, exhibiting good selectivity towards MAOs. JBI-802 demonstrates antiproliferative activity against multiple cell lines including AML, CLL, and SCLC, inhibiting tumour growth.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,93010-14 weeks10-14 weeks
50 mg$2,61010-14 weeks10-14 weeks
100 mg$3,33010-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
LSD1/HDAC6-IN-2 (JBI-802) is an orally active inhibitor of LSD1/HDAC6/HDAC8 with IC₅₀ values of 50 nM, 11 nM, and 98 nM respectively, exhibiting good selectivity towards MAOs. JBI-802 demonstrates antiproliferative activity against multiple cell lines including AML, CLL, and SCLC, inhibiting tumour growth.
Targets&IC50
MAO-A:5 nM, LSD1:5 nM, HDAC6:11 nM, MAO-B:6600 nM
In vitro
LSD1/HDAC6-IN-2 (JBI-802) exhibits growth inhibitory activity against multiple myeloma cells MM.1S, MM.1R, and RPMI-8226, with EC50 values of 2 nM, 6 nM, and 280 nM, respectively [1].
In vivo
LSD1/HDAC6-IN-2 (JBI-802), administered orally at a dosage of 25 mg/kg once daily for 12 days, exhibits antitumor activity in a mouse model of multiple myeloma [1].
Chemical Properties
Molecular Weight443.34
FormulaC21H23BrN4O2
Cas No.2982787-50-6
SmilesN(CC1=CN(CC2=CC=C(C(NO)=O)C=C2)N=C1)[C@H]3[C@@H](C3)C4=CC=CC=C4.Br
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: ≥ 80 mg/mL, Sonication is recommended.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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