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Tyk2-IN-5

Name: Tyk2-IN-5
Brand: TargetMol
SKU: T13234
Rating: 4.5 (1 reviews)

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Catalog No. T13234Cas No. 1797432-62-2

Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).

Tyk2-IN-5

😃Good

Catalog No. T13234Cas No. 1797432-62-2

Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).

Pack Size	Price	Availability
5 mg	$446	6-8 weeks
25 mg	$1,430	6-8 weeks
50 mg	$1,860	6-8 weeks
100 mg	$2,800	6-8 weeks

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Product Introduction

Bioactivity

Description	Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).
Targets&IC50	TYK2 JH1:0.086 nM (ki), IFN-α:25 nM

Chemical Properties

Molecular Weight	434.43
Formula	C₂₁H₁₉FN₈O₂
Cas No.	1797432-62-2
Relative Density.	1.58 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 43.33 mg/mL (99.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3019 mL	11.5093 mL	23.0187 mL	115.0933 mL
5 mM	0.4604 mL	2.3019 mL	4.6037 mL	23.0187 mL
10 mM	0.2302 mL	1.1509 mL	2.3019 mL	11.5093 mL
20 mM	0.1151 mL	0.5755 mL	1.1509 mL	5.7547 mL
50 mM	0.0460 mL	0.2302 mL	0.4604 mL	2.3019 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc