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Glabridin
🥰Excellent
Catalog No. T3403Cas No. 59870-68-7
Alias Q-100692, LS-176045, KB-289522
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
Glabridin
🥰Excellent
Purity: 99.99%
Catalog No. T3403Alias Q-100692, LS-176045, KB-289522Cas No. 59870-68-7
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $31 | In Stock | |
| 25 mg | $53 | In Stock | |
| 50 mg | $81 | In Stock | |
| 100 mg | $129 | In Stock | |
| 500 mg | $326 | In Stock |
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Purity:99.99%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells. |
| Targets&IC50 | α1β2γ2 GABAA receptor:6.3 μM(EC50), PPARγ:6.1 μM (EC50), α1β2 GABAA receptor:9.63 μM(EC50), α1β3γ2 GABAA receptor:6.83 μM(EC50), α1β1γ2 GABAA receptor:17.23 μM(EC50) |
| Synonyms | Q-100692, LS-176045, KB-289522 |
| Molecular Weight | 324.37 |
| Formula | C20H20O4 |
| Cas No. | 59870-68-7 |
| Smiles | CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c1ccc(O)cc1O |
| Relative Density. | 1.257 g/cm3 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 76 mg/mL (234.3 mM), Sonication is recommended.  Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α1β3γ2 GABAA receptorα1β2γ2 GABAA receptorα1β2 GABAA receptorα1β1γ2 GABAA receptorT3 tyrosinaseT1 tyrosinaseReactiveOxygenSpeciesReactive Oxygen SpeciesQ100692Q 100692PPARPeroxisome proliferator-activated receptorsLS176045LS 176045KB289522KB 289522InhibitorinhibitGlabridinGABAReceptorGABA ReceptorBacterial
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