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Glabridin

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Catalog No. T3403Cas No. 59870-68-7
Alias Q-100692, LS-176045, KB-289522

Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.

Glabridin

Glabridin

😃Good
Purity: 99.99%
Catalog No. T3403Alias Q-100692, LS-176045, KB-289522Cas No. 59870-68-7
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$31In StockIn Stock
25 mg$53In StockIn Stock
50 mg$81In StockIn Stock
100 mg$129In StockIn Stock
500 mg$326BackorderBackorder
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.99%
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COA HNMR HPLC LCMS

Product Introduction

Bioactivity
Description
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
Targets&IC50
α1β2γ2 GABAA receptor:6.3 μM(EC50), PPARγ:6.1 μM (EC50), α1β2 GABAA receptor:9.63 μM(EC50), α1β3γ2 GABAA receptor:6.83 μM(EC50), α1β1γ2 GABAA receptor:17.23 μM(EC50)
SynonymsQ-100692, LS-176045, KB-289522
Chemical Properties
Molecular Weight324.37
FormulaC20H20O4
Cas No.59870-68-7
SmilesCC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c1ccc(O)cc1O
Relative Density.1.257 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 76 mg/mL (234.3 mM), Sonication is recommended.
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.17 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0829 mL15.4145 mL30.8290 mL154.1450 mL
5 mM0.6166 mL3.0829 mL6.1658 mL30.8290 mL
10 mM0.3083 mL1.5414 mL3.0829 mL15.4145 mL
20 mM0.1541 mL0.7707 mL1.5414 mL7.7072 mL
50 mM0.0617 mL0.3083 mL0.6166 mL3.0829 mL
100 mM0.0308 mL0.1541 mL0.3083 mL1.5414 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

α1β3γ2 GABAA receptorα1β2γ2 GABAA receptorα1β2 GABAA receptorα1β1γ2 GABAA receptorT3 tyrosinaseT1 tyrosinaseReactiveOxygenSpeciesReactive Oxygen SpeciesQ100692Q 100692PPARPeroxisome proliferator-activated receptorsLS176045LS 176045KB289522KB 289522InhibitorinhibitGlabridinGABAReceptorGABA ReceptorBacterial
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