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Glabridin
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Catalog No. T3403Cas No. 59870-68-7
Alias Q-100692, LS-176045, KB-289522
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
Glabridin
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Purity: 99.99%
Catalog No. T3403Alias Q-100692, LS-176045, KB-289522Cas No. 59870-68-7
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $31 | In Stock | In Stock | |
| 25 mg | $53 | In Stock | In Stock | |
| 50 mg | $81 | In Stock | In Stock | |
| 100 mg | $129 | In Stock | In Stock | |
| 500 mg | $326 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.99%
Color:White
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Product Introduction
Glabridin AI Summary
Glabridin exhibits a diverse range of bioactivities, including antibacterial, antifungal, antiviral, and anti-inflammatory properties. It shows significant antibacterial activity against Staphylococcus aureus and Mycobacterium smegmatis with a MIC of 6.25 µg/mL and antifungal activity against Candida albicans with a MIC of 25.0 µg/mL. The compound is also effective against methicillin-resistant Staphylococcus aureus and demonstrates potentiation of norfloxacin-induced activity.
In antiviral assays, Glabridin demonstrates 15.53% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM and reduces SARS-CoV-2 induced cytotoxicity in VERO-6 cells by 40.09% at 10 µM. Furthermore, it shows cytotoxicity against human HepG2 cells with an IC50 of 12800.0 nM.
The compound also exhibits bioactivity by inhibiting testosterone-5-alpha-reductase with significant inhibition at concentrations of 50 and 100 µg/mL. It binds to and activates paraoxonase-1, with a KSV value of 1.93 x 10^5 /M and a Ka value of 2.4 x 10^5 /M. Glabridin inhibits recombinant human PTP1B and tyrosinase, with a potent IC50 of 90.0 nM for the latter.
Additionally, Glabridin activates the Nrf2 pathway in human HepG2 cells and shows inhibition of NF-kappaB transcription (>30% at 10 µM) in SW480 cells. In other assays, it exhibits inhibitory effects on cytochrome P450 enzymes, including CYP3A4 and CYP2B6, and displays anti-obesity activity in mouse models fed a high-fat diet.
Overall, Glabridin is a multi-functional bioactive molecule with potential applications in treating bacterial infections, fungal infections, viral infections, inflammation, cancer, and metabolic disorders..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells. |
| Targets&IC50 | α1β1γ2 GABAA receptor:17.23 μM(EC50), α1β2 GABAA receptor:9.63 μM(EC50), α1β3γ2 GABAA receptor:6.83 μM(EC50), PPARγ:6.1 μM (EC50), α1β2γ2 GABAA receptor:6.3 μM(EC50) |
| Synonyms | Q-100692, LS-176045, KB-289522 |
| Molecular Weight | 324.37 |
| Formula | C20H20O4 |
| Cas No. | 59870-68-7 |
| Smiles | CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c1ccc(O)cc1O |
| Relative Density. | 1.257 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 76 mg/mL (234.3 mM), Sonication is recommended.  Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.17 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α1β3γ2 GABAA receptorα1β2γ2 GABAA receptorα1β2 GABAA receptorα1β1γ2 GABAA receptorT3 tyrosinaseT1 tyrosinaseReactiveOxygenSpeciesReactive Oxygen SpeciesQ100692Q 100692PPARPeroxisome proliferator-activated receptorsLS176045LS 176045KB289522KB 289522InhibitorinhibitGlabridinGABAReceptorGABA ReceptorBacterial
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