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SMS1-IN-1

Name: SMS1-IN-1
Brand: TargetMol
SKU: T12937
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12937Cas No. 1807943-38-9

SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies.

SMS1-IN-1

🥰Excellent

Purity: 99.81%

Catalog No. T12937Cas No. 1807943-38-9

SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies.

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$163	In Stock
10 mg	$228	In Stock
25 mg	$372	In Stock
50 mg	$588	In Stock
100 mg	$868	In Stock
200 mg	$1,170	In Stock
1 mL x 10 mM (in DMSO)	$196	In Stock

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Batch Information

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Purity:99.81%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies.
Targets&IC50	SMS1:2.1 μM
In vitro	SMS1-IN-1 (2.5, 10 and 50 μM) shows inhibitory effect against SMS1 in a dose-dependent manner[1].

Chemical Properties

Molecular Weight	503.41
Formula	C₂₃H₂₃BrN₂O₄S
Cas No.	1807943-38-9
Smiles	Brc1ccc(CNC(=O)COc2ccc(cc2)S(=O)(=O)NCCc2ccccc2)cc1
Relative Density.	1.409 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (486.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9865 mL	9.9323 mL	19.8645 mL	99.3226 mL
5 mM	0.3973 mL	1.9865 mL	3.9729 mL	19.8645 mL
10 mM	0.1986 mL	0.9932 mL	1.9865 mL	9.9323 mL
20 mM	0.0993 mL	0.4966 mL	0.9932 mL	4.9661 mL
50 mM	0.0397 mL	0.1986 mL	0.3973 mL	1.9865 mL
100 mM	0.0199 mL	0.0993 mL	0.1986 mL	0.9932 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc