Shopping Cart
Remove All
Your shopping cart is currently empty
XL413 xHCl
Copy Product Info
😃Good
Catalog No. T71339Cas No. 1169562-71-3
Alias XL-413 Hydrochloride, BMS-863233 HCl, BMS-863233 xHCl
XL413 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.XL413 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.XL413 HCl showed an EC50 value of 118 against pMCM.
XL413 xHCl
Copy Product Info😃Good
Purity: 99.48%
Catalog No. T71339Alias XL-413 Hydrochloride, BMS-863233 HCl, BMS-863233 xHClCas No. 1169562-71-3
XL413 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.XL413 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.XL413 HCl showed an EC50 value of 118 against pMCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $57 | In Stock | In Stock | |
| 5 mg | $122 | In Stock | In Stock | |
| 10 mg | $169 | In Stock | In Stock | |
| 25 mg | $296 | In Stock | In Stock | |
| 50 mg | $497 | In Stock | In Stock | |
| 100 mg | $723 | In Stock | In Stock | |
| 500 mg | $1,520 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.48%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | XL413 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.XL413 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.XL413 HCl showed an EC50 value of 118 against pMCM. |
| Targets&IC50 | CK2:215 nM, CDC7:3.4 nM, pMCM:118 nM(EC50), Pim1:42 nM |
| In vitro | XL413 HCl shows cytotoxic effects on tumors, with IC50 of 22.9 µM in HCC1954 cells and 1.1 µM in Colo-205 cells.[2]
BMS-863233 HCl is an effective DDK inhibitor in vitro, with an IC50 of 22.7 nM.[2] XL413 HCl is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.[2] |
| In vivo | XL413 HCl (10, 30, or 100 mg/kg; p.o.; mice) is well tolerated at all doses, with no significant body weight loss.[1]
XL413 HCl (100 mg/kg; p.o.; mice) show excellent plasma exposures in mice and possesses good PK properties.[1] |
| Synonyms | XL-413 Hydrochloride, BMS-863233 HCl, BMS-863233 xHCl |
| Molecular Weight | 326.18 |
| Formula | C14H12ClN3O2.xHCl |
| Cas No. | 1169562-71-3 |
| Smiles | Cl.Clc1ccc2oc3c(nc([nH]c3=O)[C@@H]3CCCN3)c2c1 |lp:0:3,1:3,6:2,9:1,11:1,13:2,18:1| |
| Relative Density. | No data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 9.00 mg/mL (27.59 mM), Sonication is recommended. DMSO: 3.10 mg/mL (9.50 mM), Sonication and heating are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
H2O
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy XL413 xHCl | purchase XL413 xHCl | XL413 xHCl cost | order XL413 xHCl | XL413 xHCl chemical structure | XL413 xHCl in vivo | XL413 xHCl in vitro | XL413 xHCl formula | XL413 xHCl molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.