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BMS-863233 HCl

Catalog No. T71339 CAS 1169562-71-3

Synonyms: XL413 hydrochloride

BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.BMS-863233 HCl showed an EC50 value of 118 against pMCM.

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BMS-863233 HCl, CAS 1169562-71-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 57.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 169.00
25 mg	In stock	$ 296.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 723.00
500 mg	In stock	$ 1,520.00

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Purity: 99.67%

Purity: 99.42%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.BMS-863233 HCl showed an EC50 value of 118 against pMCM.
Targets&IC50	CK2:215 nM, CDC7:3.4 nM, pMCM:118 nM(EC50), Pim1:42 nM
In vitro	BMS-863233 HCl shows cytotoxic effects on tumors, with IC50 of 22.9 µM in HCC1954 cells and 1.1 µM in Colo-205 cells.[2] BMS-863233 HCl is an effective DDK inhibitor in vitro, with an IC50 of 22.7 nM.[2] BMS-863233 HCl is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.[2]
In vivo	BMS-863233 HCl (10, 30, or 100 mg/kg; p.o.; mice) is well tolerated at all doses, with no significant body weight loss.[1] BMS-863233 HCl (100 mg/kg; p.o.; mice) show excellent plasma exposures in mice and possesses good PK properties.[1]

Synonyms	XL413 hydrochloride
Molecular Weight	326.18
Formula	C14H13Cl2N3O2
CAS No.	1169562-71-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 9.0 mg/mL (27.6 mM), Sonication is recommended.

DMSO: 3.1 mg/mL (9.4 mM), Sonication and heating are recommended.

References and Literature

1. Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor [published correction appears in Bioorg Med Chem Lett. 2012 Aug 1;22(15):5157]. Bioorg Med Chem Lett. 2012;22(11):3727-3731. 2. Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014;9(11):e113300.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Kinase Inhibitor Library Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Anti-Cancer Compound Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-863233 HCl 1169562-71-3 Cell Cycle/Checkpoint Chromatin/Epigenetic JAK/STAT signaling Metabolism Stem Cells CDK Pim Casein Kinase XL413 hydrochloride XL413 Hydrochloride XL 413 Hydrochloride XL-413 Hydrochloride inhibitor inhibit

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