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Darodipine

Name: Darodipine
Brand: TargetMol
SKU: T15053
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15053Cas No. 72803-02-2

Alias PY-108068, PY 108-068

Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.

Darodipine

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Purity: 99.67%

Catalog No. T15053Alias PY-108068, PY 108-068Cas No. 72803-02-2

Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$67	In Stock	In Stock
10 mg	$94	In Stock	In Stock
25 mg	$173	In Stock	In Stock
50 mg	$298	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.67%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.
In vivo	Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. Darodipine (10 mg/kg; 6-month (from the 18th to the 24th month of life); p.o.) treatment restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex [2]. Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon's horn is the most sensitive to treatment with darodipine [1].
Synonyms	PY-108068, PY 108-068

Chemical Properties

Molecular Weight	371.39
Formula	C₁₉H₂₁N₃O₅
Cas No.	72803-02-2
Smiles	C(OCC)(=O)C=1C(C(C(OCC)=O)=C(C)NC1C)C=2C=3C(C=CC2)=NON3
Relative Density.	1.251g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (161.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6926 mL	13.4629 mL	26.9259 mL	134.6294 mL
5 mM	0.5385 mL	2.6926 mL	5.3852 mL	26.9259 mL
10 mM	0.2693 mL	1.3463 mL	2.6926 mL	13.4629 mL
20 mM	0.1346 mL	0.6731 mL	1.3463 mL	6.7315 mL
50 mM	0.0539 mL	0.2693 mL	0.5385 mL	2.6926 mL
100 mM	0.0269 mL	0.1346 mL	0.2693 mL	1.3463 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc