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O6BTG-octylglucoside

Name: O6BTG-octylglucoside
Brand: TargetMol
SKU: T11419
Rating: 4.5 (1 reviews)

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Catalog No. T11419Cas No. 382607-78-5

Alias Glucose-conjugated MGMT inhibitor

O6BTG-octylglucoside is a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) with IC50 values of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extracts).

O6BTG-octylglucoside

😃Good

Catalog No. T11419Alias Glucose-conjugated MGMT inhibitorCas No. 382607-78-5

O6BTG-octylglucoside is a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) with IC50 values of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extracts).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$95	5 days	5 days
5 mg	$163	5 days	5 days
1 mL x 10 mM (in DMSO)	$268	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	O6BTG-octylglucoside is a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) with IC50 values of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extracts).
Targets&IC50	MGMT:32 nM
In vitro	O6BTG-octylglucoside is a potent and non-toxic MGMT inhibitor, demonstrating IC50s of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extracts).
Synonyms	Glucose-conjugated MGMT inhibitor

Chemical Properties

Molecular Weight	616.53
Formula	C₂₄H₃₄BrN₅O₇S
Cas No.	382607-78-5
Relative Density.	1.70 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (162.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.35 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6220 mL	8.1099 mL	16.2198 mL	81.0991 mL
5 mM	0.3244 mL	1.6220 mL	3.2440 mL	16.2198 mL
10 mM	0.1622 mL	0.8110 mL	1.6220 mL	8.1099 mL
20 mM	0.0811 mL	0.4055 mL	0.8110 mL	4.0550 mL
50 mM	0.0324 mL	0.1622 mL	0.3244 mL	1.6220 mL
100 mM	0.0162 mL	0.0811 mL	0.1622 mL	0.8110 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc