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O6BTG-octylglucoside

Name: O6BTG-octylglucoside
Brand: TargetMol
SKU: T11419
Rating: 4.5 (1 reviews)

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Catalog No. T11419Cas No. 382607-78-5

Alias Glucose-conjugated MGMT inhibitor

O6BTG-octylglucoside is a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) with IC50 values of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extracts).

O6BTG-octylglucoside

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Catalog No. T11419Alias Glucose-conjugated MGMT inhibitorCas No. 382607-78-5

O6BTG-octylglucoside is a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) with IC50 values of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extracts).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$95	5 days	5 days
5 mg	$163	5 days	5 days
1 mL x 10 mM (in DMSO)	$268	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	O6BTG-octylglucoside is a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) with IC50 values of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extracts).
Targets&IC50	MGMT:32 nM
In vitro	O6BTG-octylglucoside is a potent and non-toxic MGMT inhibitor, demonstrating IC50s of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extracts).
Synonyms	Glucose-conjugated MGMT inhibitor

Chemical Properties

Molecular Weight	616.53
Formula	C₂₄H₃₄BrN₅O₇S
Cas No.	382607-78-5
Smiles	[H][C@]1(CO)O[C@@]([H])(OCCCCCCCCn2cnc3c(OCc4cc(Br)cs4)nc(N)nc23)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O
Relative Density.	1.70 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (162.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6220 mL	8.1099 mL	16.2198 mL	81.0991 mL
5 mM	0.3244 mL	1.6220 mL	3.2440 mL	16.2198 mL
10 mM	0.1622 mL	0.8110 mL	1.6220 mL	8.1099 mL
20 mM	0.0811 mL	0.4055 mL	0.8110 mL	4.0550 mL
50 mM	0.0324 mL	0.1622 mL	0.3244 mL	1.6220 mL
100 mM	0.0162 mL	0.0811 mL	0.1622 mL	0.8110 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc