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Anti-ABRAXAS1 Antibody (4Z976) (Synonyms: FAM175A, ABRAXAS, ABRA1)
Catalog No. TMAB-02178 Copy Product Info
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Anti-ABRAXAS1 Antibody (4Z976) is a Rabbit antibody targeting ABRAXAS1. Anti-ABRAXAS1 Antibody (4Z976) can be used in FCM, ICC/IF, IP, WB.
Anti-ABRAXAS1 Antibody (4Z976)
Copy Product Info🥰Excellent
Catalog No. TMAB-02178
Synonyms FAM175A, ABRAXAS, ABRA1
Anti-ABRAXAS1 Antibody (4Z976) is a Rabbit antibody targeting ABRAXAS1. Anti-ABRAXAS1 Antibody (4Z976) can be used in FCM, ICC/IF, IP, WB.
Anti-ABRAXAS1 Antibody
(4Z976)
(4Z976)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-ABRAXAS1 Antibody (4Z976) is a Rabbit antibody targeting ABRAXAS1. Anti-ABRAXAS1 Antibody (4Z976) can be used in FCM, ICC/IF, IP, WB. |
| Synonyms | FAM175A, ABRAXAS, ABRA1 |
| Ig Type | IgG |
| Clone | 4Z976 |
| Reactivity | Human |
| Verified Activity | 25 ug total protein per lane of various lysates (see on figure) probed with ABRAXAS1 monoclonal antibody, unconjugated (TMAB-02178) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | FCM=1:50-100; ICC/IF=1:50-200; IP=1:20-50; WB=1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. |
| Immunogen | A synthesized peptide: human ABRAXAS1 |
| Antigen Species | Human |
| Gene Name | ABRAXAS1 |
| Gene ID | |
| Protein Name | BRCA1-A complex subunit Abraxas 1 |
| Uniprot ID | |
| Function | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. |
| Molecular Weight | Theoretical: 47 kDa. Actual: 50 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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