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Anti-ABRAXAS1 Antibody (4Z976)
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Catalog No. TMAB-02178
Anti-ABRAXAS1 Antibody (4Z976) is a Rabbit antibody targeting ABRAXAS1. Anti-ABRAXAS1 Antibody (4Z976) can be used in FCM, ICC/IF, IP, WB.
Anti-ABRAXAS1 Antibody (4Z976)
Anti-ABRAXAS1 Antibody (4Z976)
😃Good
Catalog No. TMAB-02178
Anti-ABRAXAS1 Antibody (4Z976) is a Rabbit antibody targeting ABRAXAS1. Anti-ABRAXAS1 Antibody (4Z976) can be used in FCM, ICC/IF, IP, WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ABRAXAS1 Antibody (4Z976) is a Rabbit antibody targeting ABRAXAS1. Anti-ABRAXAS1 Antibody (4Z976) can be used in FCM, ICC/IF, IP, WB. |
| Ig Type | IgG |
| Clone | 4Z976 |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM=1:50-100; ICC/IF=1:50-200; IP=1:20-50; WB=1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. |
| Immunogen | A synthesized peptide: human ABRAXAS1 |
| Antigen Species | Human |
| Gene Name | ABRAXAS1 |
| Gene ID | |
| Protein Name | BRCA1-A complex subunit Abraxas 1 |
| Uniprot ID | |
| Function | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. |
| Molecular Weight | Theoretical: 47 kDa. Actual: 50 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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