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BI-7273

Name: BI-7273
Brand: TargetMol
SKU: T6783
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6783Cas No. 1883429-21-7

BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.

BI-7273

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🥰Excellent

Purity: 99.57%

Catalog No. T6783Cas No. 1883429-21-7

BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$239	In Stock	In Stock
50 mg	$383	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.57%

Color:White

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COA

Product Introduction

Bioactivity

Description	BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
Targets&IC50	BRD7:117 nM, BRD9:19 nM
In vitro	BI-7273 blocks EOL-1 cell proliferation with EC50 of 1400 nM. BI-7273 (1 μM) is active in U2OS cell lines. BI-7273 (10 μM) shows an inhibition below 40% against 31 kinases[1].
Cell Research	Cells are grown in 50 μL medium as specified by the supplier for 7 days starting with 500 and with 1000 cells per well of a 384 well plate in the presence of varying concentrations of compound before measuring viability via cellular ATP levels using the cell titer glow assay.

Chemical Properties

Molecular Weight	353.41
Formula	C₂₀H₂₃N₃O₃
Cas No.	1883429-21-7
Smiles	COc1cc(cc(OC)c1CN(C)C)-c1cn(C)c(=O)c2cnccc12
Relative Density.	1.189 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 65 mg/mL (183.92 mM), Sonication is recommended.

DMSO: 65 mg/mL (183.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8296 mL	14.1479 mL	28.2957 mL	141.4787 mL
5 mM	0.5659 mL	2.8296 mL	5.6591 mL	28.2957 mL
10 mM	0.2830 mL	1.4148 mL	2.8296 mL	14.1479 mL
20 mM	0.1415 mL	0.7074 mL	1.4148 mL	7.0739 mL
50 mM	0.0566 mL	0.2830 mL	0.5659 mL	2.8296 mL
100 mM	0.0283 mL	0.1415 mL	0.2830 mL	1.4148 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc