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Oxcarbazepine
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Catalog No. T0440Cas No. 28721-07-5
Alias GP 47680
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
Oxcarbazepine
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Purity: 98.46%
Catalog No. T0440Alias GP 47680Cas No. 28721-07-5
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $31 | In Stock | In Stock | |
| 10 mg | $48 | In Stock | In Stock | |
| 25 mg | $74 | In Stock | In Stock | |
| 50 mg | $93 | In Stock | In Stock | |
| 100 mg | $142 | In Stock | In Stock | |
| 200 mg | $184 | In Stock | In Stock | |
| 500 mg | $247 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $53 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.46%
Appearance:Solid
Color:White
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Product Introduction
Oxcarbazepine AI Summary
Oxcarbazepine exhibits anticonvulsant activity, demonstrating a 68.3% protection rate against MES-induced seizures in rats. It has a rapid onset of effect, with a Tmax of 0.08333 hr intraperitoneally and 2.0 hr via gastric tube. The compound’s ED50 values are 6.1 mg.kg-1 intraperitoneally and 10.0 mg.kg-1 via gastric tube. Toxicity measures include a TD50 of 40.1 mg.kg-1 in the rotarod test and greater than 1000.0 mg.kg-1 by gastric administration. It inhibits voltage-gated sodium channels in rat cortical synaptosomes with an IC50 of less than 161000.0 nM and shows dose-dependent inhibition of 22Na+ uptake.
Additionally, Oxcarbazepine inhibits the human aquaporin 4 M23 isoform at 20 µM (33% inhibition). It has good solubility in 0.1 M phosphate buffer and water and exhibits broad bioactivity, including inhibition of various human targets, chronic active B-cell receptor signaling, and more. It also influences liver and kidney function markers and shows cytotoxicity against HepG2 cells with an IC50 of 19498.45 nM.
Pharmacokinetically, Oxcarbazepine has a LogD7.4 of 1.28 and a LogP of 20.4. It has low oral bioavailability (F = 0.99%) and various AUC values depending on the assay. The compound shows significant bioactivity in modulating transport processes mediated by OATP1B1 and OATP1B3 and has antagonist activity at the P2X4 receptor, with an IC50 greater than 10,000.0 nM.
Additionally, it demonstrates a half-life of 2.0 hours and shows inhibitory activity against multiple drug transporters like BSEP, MRP2, MRP3, and MRP4. Oxcarbazepine has minimal effectiveness against SARS-CoV-2 under tested conditions but shows antibacterial and antifungal activities. Lastly, it inhibits human HDAC6 with strong potency in enzymatic assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
| Targets&IC50 | Na+ channel:160 μM |
| Synonyms | GP 47680 |
| Molecular Weight | 252.27 |
| Formula | C15H12N2O2 |
| Cas No. | 28721-07-5 |
| Smiles | C(N)(=O)N1C=2C(C(=O)CC=3C1=CC=CC3)=CC=CC2 |
| Relative Density. | 1.329g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 18 mg/mL (71.35 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.96 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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