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Nirmatrelvir

Name: Nirmatrelvir
Brand: TargetMol
SKU: T9351
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9351Cas No. 2628280-40-8

PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .

Nirmatrelvir

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Purity: 99.93%

Catalog No. T9351Cas No. 2628280-40-8

PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
2 mg	$75	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$349	In Stock	In Stock
50 mg	$539	In Stock	In Stock
100 mg	$697	In Stock	In Stock
200 mg	$995	In Stock	In Stock
500 mg	$1,490	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$136	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .
Targets&IC50	MRC5 cells:0.212 μM (EC50), Vero C1008 cells:75 nM (EC50)
In vitro	PF-07321332 is a promising oral antiviral clinical candidate with well-established anti-SARS-CoV-2 activity in vitro.
In vivo	METHODS: To assay in vivo antiviral activity, Nirmatrelvir (20 mg/kg, 2% DMSO + 20% sulfobutylether-β-cyclodextrin in 0.9% saline) and Molnupiravir (20 mg/kg) were orally administered to SARS-CoV-2 infected K18-hACE2 transgenic mice twice daily for five days. RESULTS: In lethally infected mice, the combination of Nirmatrelvir and Molnupiravir demonstrated severe inhibition of SARS-CoV-2 replication in the lungs and brain and synergistically improved survival by up to 80%. 36% survival was achieved with Nirmatrelvir alone, and 43% with Molnupiravir alone. [3]

Chemical Properties

Molecular Weight	499.53
Formula	C₂₃H₃₂F₃N₅O₄
Cas No.	2628280-40-8
Smiles	C(N[C@@H](C[C@H]1C(=O)NCC1)C#N)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(C(F)(F)F)=O)[C@](C)(C)C)=O)[H])[H]
Relative Density.	1.267 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 257.5 mg/mL (515.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 13 mg/mL (26.02 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0019 mL	10.0094 mL	20.0188 mL	100.0941 mL
5 mM	0.4004 mL	2.0019 mL	4.0038 mL	20.0188 mL
10 mM	0.2002 mL	1.0009 mL	2.0019 mL	10.0094 mL
20 mM	0.1001 mL	0.5005 mL	1.0009 mL	5.0047 mL
50 mM	0.0400 mL	0.2002 mL	0.4004 mL	2.0019 mL
100 mM	0.0200 mL	0.1001 mL	0.2002 mL	1.0009 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc