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Anti-FANCD2 Antibody (8B144) (Synonyms: Type 4 Fanconi pancytopenia, Protein FACD2, OTTHUMP00000207925, OTTHU...)
Catalog No. TMAC-01442 Copy Product Info
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Anti-FANCD2 Antibody (8B144) is a Rabbit antibody targeting FANCD2. Anti-FANCD2 Antibody (8B144) can be used in ICC/IF,IHC,IP,WB.
Anti-FANCD2 Antibody (8B144)
Copy Product Info🥰Excellent
Catalog No. TMAC-01442
Synonyms Type 4 Fanconi pancytopenia, Protein FACD2, OTTHUMP00000207925, OTTHUMP00000158853, FLJ23826, FANCONI PANCYTOPENIA TYPE 4, Fanconi anemia group D2 protein, Fanconi anemia complementation group D2, FANCONI ANEMIA COMPLEMENTATION GROUP D, FANCD2, FANCD 2, FANCD, FANC D2, FAD2, FAD, FACD2_HUMAN, FACD2, FACD 2, FACD, FAC D2, FA4, FA D2, FA 4, DKFZp762A223
Anti-FANCD2 Antibody (8B144) is a Rabbit antibody targeting FANCD2. Anti-FANCD2 Antibody (8B144) can be used in ICC/IF,IHC,IP,WB.
Anti-FANCD2 Antibody
(8B144)
(8B144)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-FANCD2 Antibody (8B144) is a Rabbit antibody targeting FANCD2. Anti-FANCD2 Antibody (8B144) can be used in ICC/IF,IHC,IP,WB. |
| Synonyms | Type 4 Fanconi pancytopenia, Protein FACD2, OTTHUMP00000207925, OTTHUMP00000158853, FLJ23826, FANCONI PANCYTOPENIA TYPE 4, Fanconi anemia group D2 protein, Fanconi anemia complementation group D2, FANCONI ANEMIA COMPLEMENTATION GROUP D, FANCD2, FANCD 2, FANCD, FANC D2, FAD2, FAD, FACD2_HUMAN, FACD2, FACD 2, FACD, FAC D2, FA4, FA D2, FA 4, DKFZp762A223 |
| Ig Type | IgG |
| Clone | 8B144 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-FANCD2 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded rat stomach tissue using anti-FANCD2 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-FANCD2 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-FANCD2 antibody. Counter stained with hematoxylin. 5. ICC staining FANCD2 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining FANCD2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining FANCD2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.        |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Fanconi anemia (FA) is an autosomal recessive disorder character-ized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least 8 complementation groups (A-G) have been identified and 6 FA genes (for subtypes A, C, D2, E, F and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC (Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451-amino acid nuclear protein that exists as 2 protein isoforms. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 166 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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