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Synonyms: P5CDh, P5CD, ALDH4, aldehyde dehydrogenase 4 family, member A1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $269 | 7-10 days | 7-10 days |
| Description | Anti-ALDH4A1 Antibody (9Z387) is a Rabbit antibody targeting ALDH4A1. Anti-ALDH4A1 Antibody (9Z387) can be used in IP,WB. |
| Synonyms | P5CDh, P5CD, ALDH4, aldehyde dehydrogenase 4 family, member A1 |
| Ig Type | Rabbit IgG |
| Clone | 9Z387 |
| Reactivity | Human |
| Specificity | Human ALDH4A1 |
| Application | |
| Recommended Dose | WB: 1:500-1:2000; IP: 1-4 μL/mg of lysate |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human ALDH4A1 (rh ALDH4A1; TMPY-02799; AAH07581.1; Lys25-Gln563). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks (amino acids). Additional aldehyde dehydrogenase enzymes detoxify external substances, such as alcohol and pollutants, and internal substances, such as toxins that are formed within cells. ALDH4A1 is expressed abundantly in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. It is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2). HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human ALDH4A1 Protein (TMPY-02799) |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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