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Tyrphostin A25
🥰Excellent
Catalog No. T21622Cas No. 118409-58-8
Alias Tyrphostin AG 82, RG-50875, AG-82
Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.3 μM for GPR35.
Tyrphostin A25
🥰Excellent
Purity: 98.98%
Catalog No. T21622Alias Tyrphostin AG 82, RG-50875, AG-82Cas No. 118409-58-8
Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.3 μM for GPR35.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $33 | - | In Stock | |
| 5 mg | $52 | In Stock | In Stock | |
| 10 mg | $75 | - | In Stock | |
| 25 mg | $123 | - | In Stock | |
| 50 mg | $182 | - | In Stock | |
| 100 mg | $269 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.3 μM for GPR35. |
| Targets&IC50 | GPR35:0.94 µM, GPR35:5.3 µM |
| In vitro | In the human epidermoid carcinoma cell line A431, Tyrphostin A25 inhibited the activity of epidermal growth factor receptor kinase with an IC50 value of 3 μM.[1] |
| Synonyms | Tyrphostin AG 82, RG-50875, AG-82 |
| Molecular Weight | 202.17 |
| Formula | C10H6N2O3 |
| Cas No. | 118409-58-8 |
| Smiles | C(=C(C#N)C#N)C1=CC(O)=C(O)C(O)=C1 |
| Relative Density. | 1.569 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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