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ER-000444793

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Catalog No. T15241Cas No. 792957-74-5

ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).

ER-000444793

ER-000444793

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Purity: 99.55%
Catalog No. T15241Cas No. 792957-74-5
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$70In StockIn Stock
5 mg$163In StockIn Stock
10 mg$247In StockIn Stock
25 mg$490In StockIn Stock
50 mg$715In StockIn Stock
100 mg$987In StockIn Stock
500 mg$1,980-In Stock
1 mL x 10 mM (in DMSO)$178In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.55%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
Targets&IC50
mPTP:2.8 μM
In vitro
ER-000444793 is a small molecule and non-toxic mPTP inhibitor. It also has a mechanism of action independent of CypD inhibition. Both CsA and SfA dose-dependently reduce HTRF signal, showing the displacement of labeled CsA from rhCypD protein (CsA IC50=23?nM and SfA IC50=?5?nM). However, ER-000444793 has no effect up to a concentration of 50?μM, showing be short of displacement of labelled-CsA from rhCypD protein. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. These data display the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition[1].
Chemical Properties
Molecular Weight354.4
FormulaC23H18N2O2
Cas No.792957-74-5
SmilesO=C(Nc1ccccc1Cc1ccccc1)c1cc(=O)[nH]c2ccccc12
Relative Density.no data available
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (141.08 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8217 mL14.1084 mL28.2167 mL141.0835 mL
5 mM0.5643 mL2.8217 mL5.6433 mL28.2167 mL
10 mM0.2822 mL1.4108 mL2.8217 mL14.1084 mL
20 mM0.1411 mL0.7054 mL1.4108 mL7.0542 mL
50 mM0.0564 mL0.2822 mL0.5643 mL2.8217 mL
100 mM0.0282 mL0.1411 mL0.2822 mL1.4108 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

mPTPMitochondrialMetabolismMitochondrial MetabolismInhibitorinhibitER-000444793ER000444793ER 000444793
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