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Antibacterial agent 27

Name: Antibacterial agent 27
Brand: TargetMol
SKU: T9612
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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🥰Excellent

Catalog No. T9612Cas No. 65795-51-9

Antibacterial agent 27 has potent anti-Candida activity.

Antibacterial agent 27

Copy Product Info

🥰Excellent

Purity: 98.91%

Catalog No. T9612Cas No. 65795-51-9

Antibacterial agent 27 has potent anti-Candida activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	In Stock	In Stock
5 mg	$88	In Stock	In Stock
10 mg	$143	In Stock	In Stock
25 mg	$268	In Stock	In Stock
50 mg	$401	In Stock	In Stock
100 mg	$596	In Stock	In Stock
200 mg	$788	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.91%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Antibacterial agent 27 AI Summary

Antibacterial agent 27 exhibits diverse and potent bioactivities, targeting a range of organisms and enzymes. It effectively inhibits Plasmodium falciparum, showing 92.0% inhibition of the 3D7 strain and 95.0% inhibition of the Dd2 strain in whole erythrocytes at 2 μM concentration. Additionally, it exhibits an XC50 value of 3.29 nM against the 3D7 strain. The compound has an Inhibition Frequency Index (IFI) of 5.0% in non-kinase HTS assays with >50% inhibition and demonstrates 64.0% inhibition of the human HepG2 cell line at a 10 μM concentration. Against Leishmania Mexicana, Antibacterial agent 27 shows significant cytotoxicity against glucose transport-deficient promastigotes and those complemented with various glucose transporters, with IC50 values ranging from 537.0 nM to 777.0 nM and inhibition percentages between 77.74% and 84.19% at 2 μM concentration. This suggests the compound may target glucose transport mechanisms in Leishmania parasites. Regarding mammalian cell lines, Antibacterial agent 27 is cytotoxic to mouse L1210 cells with an IC50 of 40.0 nM. It is also a potent inhibitor of dihydrofolate reductase (DHFR), with IC50 values of 6.4 nM in Lactobacillus casei, 0.7 nM in Crithidia oncopelti, 2.1 nM in rat liver DHFR, and 4.0 nM in mouse L1210 cells. Furthermore, it inhibits human DHFR and Mycobacterium tuberculosis DHFR with IC50 values of 6.8 nM and 10.1 nM, respectively. The compound also shows antimicrobial activity against Mycobacterium tuberculosis H37Rv in human THP1 cells, with a MIC90 value of 500.0 nM. These findings indicate that Antibacterial agent 27 has significant cytotoxic, antimalarial, anti-leishmanial, and antimicrobial properties, making it a promising candidate for further drug development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Antibacterial agent 27 has potent anti-Candida activity.

Chemical Properties

Molecular Weight	314.34
Formula	C₁₈H₁₄N₆
Cas No.	65795-51-9
Smiles	Nc1nc(N)c2c3ccn(Cc4ccc(cc4)C#N)c3ccc2n1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (318.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1813 mL	15.9063 mL	31.8127 mL	159.0634 mL
5 mM	0.6363 mL	3.1813 mL	6.3625 mL	31.8127 mL
10 mM	0.3181 mL	1.5906 mL	3.1813 mL	15.9063 mL
20 mM	0.1591 mL	0.7953 mL	1.5906 mL	7.9532 mL
50 mM	0.0636 mL	0.3181 mL	0.6363 mL	3.1813 mL
100 mM	0.0318 mL	0.1591 mL	0.3181 mL	1.5906 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc