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VHL Ligand 14
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Catalog No. T87617Cas No. 2010986-87-3
VHL Ligand 14 (Compound 11), a VHL ligand engineered for creating PROTAC estrogen receptor α (ERα) degraders, exhibits a binding affinity with an IC50 of 196 nM [1].
VHL Ligand 14
😃Good
Catalog No. T87617Cas No. 2010986-87-3
VHL Ligand 14 (Compound 11), a VHL ligand engineered for creating PROTAC estrogen receptor α (ERα) degraders, exhibits a binding affinity with an IC50 of 196 nM [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry |
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Product Introduction
Bioactivity
Chemical Properties
| Description | VHL Ligand 14 (Compound 11), a VHL ligand engineered for creating PROTAC estrogen receptor α (ERα) degraders, exhibits a binding affinity with an IC50 of 196 nM [1]. |
| In vitro | VHL Ligand 14 (5-10 μM) stabilizes the ER degrader in PROTAC, facilitating the degradation of ER [1]. Using Western Blot Analysis [1] with the MCF-7 cell line at a concentration of 5-10 μM over a 4-hour incubation period, it was found to inhibit the degradation of the ER ligand. |
| Molecular Weight | 486.63 |
| Formula | C25H34N4O4S |
| Cas No. | 2010986-87-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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