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Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2

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Catalog No. TMAB-11265

Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-RUNX1 (Ser249). Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.

Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2

Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2

😃Good
Catalog No. TMAB-11265
Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-RUNX1 (Ser249). Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5287-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-RUNX1 (Ser249). Anti-Phospho-RUNX1 (Ser249) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Rabbit,GuineaPig)
Application
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
Tissue SpecificityExpressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
KLH conjugated synthesised phosphopeptide: human RUNX1 around the phosphorylation site of Ser249
Antigen Species
Human
Gene Name
RUNX1
Gene ID
Protein Name
Runt-related transcription factor 1
Uniprot ID
Function
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.
Chemical Properties
Molecular WeightTheoretical: 50 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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