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BAY 73-1449

Name: BAY 73-1449
Brand: TargetMol
SKU: T26745
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T26745Cas No. 693790-96-4

Alias BAY73-1449, BAY-73-1449

BAY 73-1449 is a potent and selective antagonist of the prostacyclin receptor (IC50 < 0.1 nM).

BAY 73-1449

🥰Excellent

Purity: 99.77%

Catalog No. T26745Alias BAY73-1449, BAY-73-1449Cas No. 693790-96-4

BAY 73-1449 is a potent and selective antagonist of the prostacyclin receptor (IC50 < 0.1 nM).

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$83	In Stock
10 mg	$138	In Stock
25 mg	$239	In Stock
50 mg	$343	In Stock
100 mg	$457	In Stock
200 mg	$615	In Stock
1 mL x 10 mM (in DMSO)	$95	In Stock

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Batch Information

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Purity:99.77%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BAY 73-1449 is a potent and selective antagonist of the prostacyclin receptor (IC50 < 0.1 nM).
Targets&IC50	Prostacyclin receptor:<0.1 nM
In vivo	In male Wistar rats, BAY 73-1449 (0.1-1 mg/kg; i.v.) significantly reduced splenic shunt vessel outflow without affecting mesenteric inflow[1]. BAY 73-1449 (1-5 mg/kg; s.c.) has no effects on portal pressures and the degree of porto-systemic shunting in rats[1].
Synonyms	BAY73-1449, BAY-73-1449

Chemical Properties

Molecular Weight	425.48
Formula	C₂₆H₂₃N₃O₃
Cas No.	693790-96-4
Smiles	OC(=O)[C@@H](Cc1ccccc1)Nc1cc(ncn1)-c1ccc(OCc2ccccc2)cc1
Relative Density.	1.273 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/ml (129.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3503 mL	11.7514 mL	23.5029 mL	117.5143 mL
5 mM	0.4701 mL	2.3503 mL	4.7006 mL	23.5029 mL
10 mM	0.2350 mL	1.1751 mL	2.3503 mL	11.7514 mL
20 mM	0.1175 mL	0.5876 mL	1.1751 mL	5.8757 mL
50 mM	0.0470 mL	0.2350 mL	0.4701 mL	2.3503 mL
100 mM	0.0235 mL	0.1175 mL	0.2350 mL	1.1751 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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