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GSK180

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Catalog No. T15426Cas No. 1799725-26-0
Alias GSK-180, GSK180, GSK 180

GSK180 is a selective, competitive, and highly potent inhibitor of kynurenine-3-monooxygenase (KMO), a critical enzyme in the tryptophan metabolic pathway, with an IC50 value of approximately 6 nM, displaying minimal off-target activity against other tryptophan pathway enzymes, rapidly altering kynurenine metabolite profiles, GSK180 serves as a powerful research tool for probing the biological and therapeutic implications of KMO inhibition in metabolic, neurological, and inflammatory disease models.

GSK180

GSK180

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Catalog No. T15426Alias GSK-180, GSK180, GSK 180Cas No. 1799725-26-0
GSK180 is a selective, competitive, and highly potent inhibitor of kynurenine-3-monooxygenase (KMO), a critical enzyme in the tryptophan metabolic pathway, with an IC50 value of approximately 6 nM, displaying minimal off-target activity against other tryptophan pathway enzymes, rapidly altering kynurenine metabolite profiles, GSK180 serves as a powerful research tool for probing the biological and therapeutic implications of KMO inhibition in metabolic, neurological, and inflammatory disease models.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$74-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
GSK180 is a selective, competitive, and highly potent inhibitor of kynurenine-3-monooxygenase (KMO), a critical enzyme in the tryptophan metabolic pathway, with an IC50 value of approximately 6 nM, displaying minimal off-target activity against other tryptophan pathway enzymes, rapidly altering kynurenine metabolite profiles, GSK180 serves as a powerful research tool for probing the biological and therapeutic implications of KMO inhibition in metabolic, neurological, and inflammatory disease models.
Targets&IC50
KMO:6 nM
In vitro
GSK180 inhibits endogenous KMO activity in primary human hepatocytes (IC50=2.6 μM) and it also inhibits rat KMO slightly less potently than the human enzyme (IC50=7 μM).
In vivo
GSK180 is fit for i.v. management [1].
SynonymsGSK-180, GSK180, GSK 180
Chemical Properties
Molecular Weight276.07
FormulaC10H7Cl2NO4
Cas No.1799725-26-0
SmilesO=C(O)CCN1C(=O)OC2=CC(Cl)=C(Cl)C=C21
Relative Density.1.626 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (724.45 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6223 mL18.1113 mL36.2227 mL181.1135 mL
5 mM0.7245 mL3.6223 mL7.2445 mL36.2227 mL
10 mM0.3622 mL1.8111 mL3.6223 mL18.1113 mL
20 mM0.1811 mL0.9056 mL1.8111 mL9.0557 mL
50 mM0.0724 mL0.3622 mL0.7245 mL3.6223 mL
100 mM0.0362 mL0.1811 mL0.3622 mL1.8111 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KMO
Related Tags: buy GSK180 | purchase GSK180 | GSK180 cost | order GSK180 | GSK180 chemical structure | GSK180 in vivo | GSK180 in vitro | GSK180 formula | GSK180 molecular weight
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