Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

GSK180

😃Good
Catalog No. T15426Cas No. 1799725-26-0
Alias GSK-180, GSK180, GSK 180

GSK180 is a selective, competitive, and highly potent inhibitor of kynurenine-3-monooxygenase (KMO), a critical enzyme in the tryptophan metabolic pathway, with an IC50 value of approximately 6 nM, displaying minimal off-target activity against other tryptophan pathway enzymes, rapidly altering kynurenine metabolite profiles, GSK180 serves as a powerful research tool for probing the biological and therapeutic implications of KMO inhibition in metabolic, neurological, and inflammatory disease models.

GSK180

GSK180

😃Good
Catalog No. T15426Alias GSK-180, GSK180, GSK 180Cas No. 1799725-26-0
GSK180 is a selective, competitive, and highly potent inhibitor of kynurenine-3-monooxygenase (KMO), a critical enzyme in the tryptophan metabolic pathway, with an IC50 value of approximately 6 nM, displaying minimal off-target activity against other tryptophan pathway enzymes, rapidly altering kynurenine metabolite profiles, GSK180 serves as a powerful research tool for probing the biological and therapeutic implications of KMO inhibition in metabolic, neurological, and inflammatory disease models.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$86-In Stock
5 mg$1405 days5 days
1 mL x 10 mM (in DMSO)$1335 days5 days
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Contact us for more batch information

Resource Download

COA

Product Introduction

Bioactivity
Description
GSK180 is a selective, competitive, and highly potent inhibitor of kynurenine-3-monooxygenase (KMO), a critical enzyme in the tryptophan metabolic pathway, with an IC50 value of approximately 6 nM, displaying minimal off-target activity against other tryptophan pathway enzymes, rapidly altering kynurenine metabolite profiles, GSK180 serves as a powerful research tool for probing the biological and therapeutic implications of KMO inhibition in metabolic, neurological, and inflammatory disease models.
Targets&IC50
KMO:6 nM
In vitro
GSK180 inhibits endogenous KMO activity in primary human hepatocytes (IC50=2.6 μM) and it also inhibits rat KMO slightly less potently than the human enzyme (IC50=7 μM).
In vivo
GSK180 is fit for i.v. management [1].
SynonymsGSK-180, GSK180, GSK 180
Chemical Properties
Molecular Weight276.07
FormulaC10H7Cl2NO4
Cas No.1799725-26-0
SmilesO=C(O)CCN1C(=O)OC2=CC(Cl)=C(Cl)C=C21
Relative Density.1.626 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (724.45 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6223 mL18.1113 mL36.2227 mL181.1135 mL
5 mM0.7245 mL3.6223 mL7.2445 mL36.2227 mL
10 mM0.3622 mL1.8111 mL3.6223 mL18.1113 mL
20 mM0.1811 mL0.9056 mL1.8111 mL9.0557 mL
50 mM0.0724 mL0.3622 mL0.7245 mL3.6223 mL
100 mM0.0362 mL0.1811 mL0.3622 mL1.8111 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KMO
Related Tags: buy GSK180 | purchase GSK180 | GSK180 cost | order GSK180 | GSK180 chemical structure | GSK180 in vivo | GSK180 in vitro | GSK180 formula | GSK180 molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.