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Limonin

Name: Limonin
Brand: TargetMol
SKU: T2728
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Obaculactone, Limonoic acid 3,19:16,17 dilactone, Dictamnolactone, Citrolimonin) Copy Product Info

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Synonyms: Obaculactone, Limonoic acid 3,19:16,17 dilactone, Dictamnolactone, Citrolimonin

Catalog No. T2728 Copy Product Info

Purity: 99.66%

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Limonin (Citrolimonin) is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

Cas No. 1180-71-8

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$41	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.66%

Color:White

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Product Introduction

Bioactivity

Description	Limonin (Citrolimonin) is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
In vivo	Limonin is an effective antiproliferative agent that inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by regulating cell apoptosis and the Wnt signaling pathway. Additionally, Limonin suppresses the replication of Human Immunodeficiency Virus-1 (HIV-1) in cultured human peripheral blood mononuclear cells (PBMC) with an EC50 of 60 μM.
Synonyms	Obaculactone, Limonoic acid 3,19:16,17 dilactone, Dictamnolactone, Citrolimonin

Chemical Properties

Molecular Weight	470.51
Formula	C₂₆H₃₀O₈
Cas No.	1180-71-8
Smiles	C[C@]12[C@]34[C@](O3)(C(=O)O[C@H]([C@]4(C)CC[C@@]1([C@]56[C@@](CC2=O)(C(C)(C)O[C@]5(CC(=O)OC6)[H])[H])[H])C=7C=COC7)[H]
Relative Density.	1.39 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (106.27 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Saline: < 5 mg/mL (10.63 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: < 5 mg/mL (10.63 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% (20% SBE-β-CD in Saline): 5 mg/mL (10.63 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1254 mL	10.6268 mL	21.2535 mL	106.2677 mL
5 mM	0.4251 mL	2.1254 mL	4.2507 mL	21.2535 mL
10 mM	0.2125 mL	1.0627 mL	2.1254 mL	10.6268 mL
20 mM	0.1063 mL	0.5313 mL	1.0627 mL	5.3134 mL
50 mM	0.0425 mL	0.2125 mL	0.4251 mL	2.1254 mL
100 mM	0.0213 mL	0.1063 mL	0.2125 mL	1.0627 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc