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(rel)-PRT062607

Name: (rel)-PRT062607
Brand: TargetMol
SKU: T9332
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9332Cas No. 1194954-52-3

Alias (rel)-P505-15

5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-, rel- can be used in research in the fields of chemistry and life sciences.

(rel)-PRT062607

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Purity: 97.11%

Catalog No. T9332Alias (rel)-P505-15Cas No. 1194954-52-3

5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-, rel- can be used in research in the fields of chemistry and life sciences.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	In Stock	In Stock
5 mg	$181	In Stock	In Stock
10 mg	$268	In Stock	In Stock
25 mg	$443	In Stock	In Stock
50 mg	$592	In Stock	In Stock
100 mg	$828	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.11%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

(rel)-PRT062607 AI Summary

(rel)-PRT062607 demonstrates multifaceted bioactivity, primarily as a potent inhibitor of Syk kinase with IC50 values of 1.0 nM to 952.0 nM across various assays and cell types, including anti-IgM stimulated human Ramos B cells. It also significantly inhibits ZAP70 (IC50 = 68.0 nM) and other kinases like PKCα (IC50 = 90.0 nM) and Lyn (IC50 = 238.0 nM). Despite its potent kinase inhibition, it shows weak inhibition of the human ERG channel (IC50 = 9100.0 nM by Q-patch) and mixed results in HDAC6 inhibition assays. The compound exhibits high plasma protein binding (PPB 89.91%-91.82%) in multiple species, low aqueous solubility (<1.0 μg/mL), minimal inhibition of CYP3A4, and an efflux ratio in Caco2 cells, indicating favorable pharmacokinetic properties. Additionally, antiviral activity against SARS-CoV-2 was noted, though with limited potency (IC50 > 20000.0 nM). These diverse bioactivities suggest (rel)-PRT062607 possesses therapeutic potential, particularly in diseases driven by kinase signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-, rel- can be used in research in the fields of chemistry and life sciences.
Synonyms	(rel)-P505-15

Chemical Properties

Molecular Weight	393.45
Formula	C₁₉H₂₃N₉O
Cas No.	1194954-52-3
Smiles	N(C=1C(C(N)=O)=CN=C(N[C@H]2[C@@H](N)CCCC2)N1)C3=CC(=CC=C3)N4N=CC=N4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (139.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5416 mL	12.7081 mL	25.4162 mL	127.0810 mL
5 mM	0.5083 mL	2.5416 mL	5.0832 mL	25.4162 mL
10 mM	0.2542 mL	1.2708 mL	2.5416 mL	12.7081 mL
20 mM	0.1271 mL	0.6354 mL	1.2708 mL	6.3540 mL
50 mM	0.0508 mL	0.2542 mL	0.5083 mL	2.5416 mL
100 mM	0.0254 mL	0.1271 mL	0.2542 mL	1.2708 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc