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HDAC-IN-7

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Catalog No. T2025Cas No. 743420-02-2

HDAC-IN-7, an analogue of Tucidinostat (Chidamide), is a HDAC inhibitor. HDAC-IN-7 inhibits acetylation of histone protein H3 and induces apoptosis in human colon cancer cell lines[1].

HDAC-IN-7

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Purity: 98.45%

Catalog No. T2025Cas No. 743420-02-2

HDAC-IN-7, an analogue of Tucidinostat (Chidamide), is a HDAC inhibitor. HDAC-IN-7 inhibits acetylation of histone protein H3 and induces apoptosis in human colon cancer cell lines[1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	-	In Stock
2 mg	$79	-	In Stock
5 mg	$139	-	In Stock
10 mg	$239	-	In Stock
25 mg	$477	-	In Stock
50 mg	$698	-	In Stock
100 mg	$993	-	In Stock
1 mL x 10 mM (in DMSO)	$119	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.45%

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COA

Product Introduction

Bioactivity

Description	HDAC-IN-7, an analogue of Tucidinostat (Chidamide), is a HDAC inhibitor. HDAC-IN-7 inhibits acetylation of histone protein H3 and induces apoptosis in human colon cancer cell lines[1].
Targets&IC50	HDAC1:95nM, HDAC3:67nM, HDAC11:432 nM, HDAC2:160nM, HDAC8:733nM, HDAC10:78 nM

Chemical Properties

Molecular Weight	390.41
Formula	C₂₂H₁₉FN₄O₂
Cas No.	743420-02-2
Smiles	N(C(=O)C1=CC=C(CNC(C=CC=2C=CC=NC2)=O)C=C1)C3=C(N)C=CC(F)=C3
Relative Density.	1.336 g/cm3 (Predicted)
Color	Brown
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (140.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5614 mL	12.8070 mL	25.6141 mL	128.0705 mL
5 mM	0.5123 mL	2.5614 mL	5.1228 mL	25.6141 mL
10 mM	0.2561 mL	1.2807 mL	2.5614 mL	12.8070 mL
20 mM	0.1281 mL	0.6404 mL	1.2807 mL	6.4035 mL
50 mM	0.0512 mL	0.2561 mL	0.5123 mL	2.5614 mL
100 mM	0.0256 mL	0.1281 mL	0.2561 mL	1.2807 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc