Shopping Cart

Your shopping cart is currently empty

F-1

Name: F-1
Brand: TargetMol
SKU: T11254
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T11254Cas No. 2244775-31-1

F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.

F-1

Copy Product Info

🥰Excellent

Purity: 97.66%

Catalog No. T11254Cas No. 2244775-31-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
5 mg	$143	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$333	In Stock	In Stock
50 mg	$470	In Stock	In Stock
100 mg	$653	In Stock	In Stock
200 mg	$888	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$177	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.66%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

F-1 AI Summary

F-1 exhibits antiproliferative activity against various cell lines harboring different genetic mutations such as NPM-ALK, EML4-ALK, SLC34A2-ROS1, and the G1202R mutation, with IC50 values ranging from 10.0 nM to 43.0 nM. It also shows inhibition of ALK and ROS cytoplasmic domains, with IC50 values in the range of 1300.0 nM to 3900.0 nM. The compound demonstrates a high potency index compared to ceritinib for ALK mutations L1196M and G1202R, with a ratio IC50 of 11.0. Additionally, it exhibits low inhibition against the EGFR cytoplasmic domain..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
Targets&IC50	ALK (L1196M):1.3 nM, ALK (G1202R):3.9 nM, ALK (WT):2.1 nM, ROS1 (WT):2.3 nM

Chemical Properties

Molecular Weight	519.02
Formula	C₂₂H₂₇ClN₈O₃S
Cas No.	2244775-31-1
Smiles	COc1nc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(C)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (192.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9267 mL	9.6335 mL	19.2671 mL	96.3354 mL
5 mM	0.3853 mL	1.9267 mL	3.8534 mL	19.2671 mL
10 mM	0.1927 mL	0.9634 mL	1.9267 mL	9.6335 mL
20 mM	0.0963 mL	0.4817 mL	0.9634 mL	4.8168 mL
50 mM	0.0385 mL	0.1927 mL	0.3853 mL	1.9267 mL
100 mM	0.0193 mL	0.0963 mL	0.1927 mL	0.9634 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc