Shopping Cart

Remove All
Your shopping cart is currently empty

F-1

Name: F-1
Brand: TargetMol
SKU: T11254
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11254Cas No. 2244775-31-1

F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.

F-1

🥰Excellent

Purity: 97.66%

Catalog No. T11254Cas No. 2244775-31-1

Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$143	In Stock
10 mg	$198	In Stock
25 mg	$333	In Stock
50 mg	$470	In Stock
100 mg	$653	In Stock
200 mg	$888	In Stock
1 mL x 10 mM (in DMSO)	$177	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.66%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
Targets&IC50	ALK (WT):2.1 nM, ALK (L1196M):1.3 nM, ROS1 (WT):2.3 nM, ALK (G1202R):3.9 nM

Chemical Properties

Molecular Weight	519.02
Formula	C₂₂H₂₇ClN₈O₃S
Cas No.	2244775-31-1
Smiles	COc1nc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(C)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (192.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9267 mL	9.6335 mL	19.2671 mL	96.3354 mL
5 mM	0.3853 mL	1.9267 mL	3.8534 mL	19.2671 mL
10 mM	0.1927 mL	0.9634 mL	1.9267 mL	9.6335 mL
20 mM	0.0963 mL	0.4817 mL	0.9634 mL	4.8168 mL
50 mM	0.0385 mL	0.1927 mL	0.3853 mL	1.9267 mL
100 mM	0.0193 mL	0.0963 mL	0.1927 mL	0.9634 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc