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AZ2

🥰Excellent
Catalog No. T36309Cas No. 2231760-33-9
Alias PI3Kγ inhibitor AZ-2

AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.

AZ2
Other Forms of AZ2:
AZ-2T68696788146-30-5
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AZ2

🥰Excellent
Purity: 99.25%
Catalog No. T36309Alias PI3Kγ inhibitor AZ-2Cas No. 2231760-33-9
AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$199-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.25%
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Product Introduction

Bioactivity
Description
AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.
Targets&IC50
PI3Kγ:9.3 (pIC50), PI3Kδ:6.6 (pIC50), PI3Kβ:4.5 (pIC50), PI3Kα:5.1 (pIC50)
In vitro
In SKOV-3 cells, the superior selectivity of AZ2 (0.1-100 nM, 1 hour) for PI3Kγ was further confirmed in the constitutively activated PI3K/Akt pathway [1].
SynonymsPI3Kγ inhibitor AZ-2
Chemical Properties
Molecular Weight369.48
FormulaC20H23N3O2S
Cas No.2231760-33-9
SmilesC[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1sc(NC(C)=O)nc1C
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (108.26 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7065 mL13.5325 mL27.0651 mL135.3253 mL
5 mM0.5413 mL2.7065 mL5.4130 mL27.0651 mL
10 mM0.2707 mL1.3533 mL2.7065 mL13.5325 mL
20 mM0.1353 mL0.6766 mL1.3533 mL6.7663 mL
50 mM0.0541 mL0.2707 mL0.5413 mL2.7065 mL
100 mM0.0271 mL0.1353 mL0.2707 mL1.3533 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

AZ2AZ 2
Related Tags: buy AZ2 | purchase AZ2 | AZ2 cost | order AZ2 | AZ2 chemical structure | AZ2 in vitro | AZ2 formula | AZ2 molecular weight
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