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MDX-1342
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Catalog No. T81829 Copy Product Info
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MDX-1342, a fully human monoclonal antibody (HuMAb), targets the CD19 membrane receptor with high specificity and affinity. It exhibits antibody-dependent cellular cytotoxicity (ADCC) and is utilized in researching B-lymphocyte malignancies and autoimmune diseases [1].
MDX-1342
Cas No. 1646327-65-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Chemical Properties
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| Description | MDX-1342, a fully human monoclonal antibody (HuMAb), targets the CD19 membrane receptor with high specificity and affinity. It exhibits antibody-dependent cellular cytotoxicity (ADCC) and is utilized in researching B-lymphocyte malignancies and autoimmune diseases [1]. |
| In vitro | MDX-1342 (0-100 μg/mL; 30 min) binds to Ramos, Raji, and ARH-77 cells, demonstrating EC50 values of 0. |
| In vivo | MDX-1342 administered intravenously at doses of 0.03, 0.3, 3, and 30 mg/kg in a 200 μL volume enhances survival in a dose-dependent manner in a mouse B-cell lymphoma model [1]. At single doses of 0.1 or 1 mg/kg, MDX-1342 exhibits low nanomolar affinity for CD19 in cynomolgus monkeys, increased binding to cynomolgus monkey FcγRIIIa, and demonstrates effective B-cell depletion in vivo [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Target | CD19 |
| Cas No. | 1646327-65-2 |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: MDX-1342 in vivo | MDX-1342 in vitro
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