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Gisadenafil besylate

Name: Gisadenafil besylate
Brand: TargetMol
SKU: T11400
Rating: 4.5 (1 reviews)

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Catalog No. T11400Cas No. 334827-98-4

Alias UK369003-26, UK 369003-26, UK 36900326

Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor (IC50=1.23 nM), 100 times more selective for PDE5 than PDE6, for the study of lower urinary tract symptoms associated with benign prostatic hyperplasia.

Gisadenafil besylate

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Catalog No. T11400Alias UK369003-26, UK 369003-26, UK 36900326Cas No. 334827-98-4

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$683	8-10 weeks	8-10 weeks
50 mg	$888	8-10 weeks	8-10 weeks
100 mg	$1,340	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor (IC50=1.23 nM), 100 times more selective for PDE5 than PDE6, for the study of lower urinary tract symptoms associated with benign prostatic hyperplasia.
In vivo	In vivo experiments used doxycycline-inducible HIV-1 Tat transgenic mice (GFAP-driven). Gisadenafil besylate was administered intraperitoneally at 0.25 mg/kg daily for 5 days. On day 5, a 5-minute hypercapnia challenge (5% CO₂) was applied to assess cerebrovascular reactivity. The treatment significantly improved the cortical blood flow response in Tat mice from 11.6% to 17.5%, and restored dilation of small arterioles (<25 μm) to 20.6%, though gisadenafil besylate did not recover the dilation of larger vessels[1].
Synonyms	UK369003-26, UK 369003-26, UK 36900326

Chemical Properties

Molecular Weight	677.79
Formula	C₂₉H₃₉N₇O₈S₂
Cas No.	334827-98-4
Smiles	O=C1N=C(NC=2C1=NN(C2CC)CCOC)C=3C=C(C=NC3OCC)S(=O)(=O)N4CCN(CC)CC4.O=S(=O)(O)C=1C=CC=CC1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 1 mg/mL (1.48 mM), Sonication is recommended.

DMSO: 80 mg/mL (118.03 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4754 mL	7.3769 mL	14.7538 mL	73.7692 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.2951 mL	1.4754 mL	2.9508 mL	14.7538 mL
10 mM	0.1475 mL	0.7377 mL	1.4754 mL	7.3769 mL
20 mM	0.0738 mL	0.3688 mL	0.7377 mL	3.6885 mL
50 mM	0.0295 mL	0.1475 mL	0.2951 mL	1.4754 mL
100 mM	0.0148 mL	0.0738 mL	0.1475 mL	0.7377 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc