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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | 7-10 days | |
500 mg | Inquiry | 7-10 days |
Description | Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1]. |
In vitro | Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride, incorporating a Degron (E3 ubiquitin ligase) and a connecting linker, is crucial in PROTAC technology. It binds to the targeting ligand to facilitate the degradation of specific proteins, including BRD4, BRD2, and BRD3[1]. |
Molecular Weight | 542.97 |
Formula | C23H31ClN4O9 |
Cas No. | 2245697-84-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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