Shopping Cart

Your shopping cart is currently empty

ZK824859 hydrochloride (2271122-53-1 free base)

Name: ZK824859 hydrochloride (2271122-53-1 free base)
Brand: TargetMol
SKU: T13409L
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T13409L

Alias ZK824859 hydrochloride

ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).

ZK824859 hydrochloride (2271122-53-1 free base)

Copy Product Info

😃Good

Catalog No. T13409LAlias ZK824859 hydrochloride

ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,820	10-14 weeks	10-14 weeks
50 mg	$2,380	10-14 weeks	10-14 weeks
100 mg	$3,100	10-14 weeks	10-14 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
Targets&IC50	TPA (human):1580 nM , Plasmin (human):1330 nM , uPA (human):79 nM
In vitro	ZK824859 is 5 fold less potent and has lost selectivity in mouse: uPA with IC50 of 410?nM; tPA with IC50 of 910?nM; plasmin with IC50 of 1600?nM compared to human IC50 of 79?nM, 1580?nM and 1330?nM respectively.
Synonyms	ZK824859 hydrochloride

Chemical Properties

Molecular Weight	464.89
Formula	C₂₃H₂₃ClF₂N₂O₄
Smiles	CC1=CC(OC2=C(F)C=C(F)C(O[C@H](CC)C(O)=O)=N2)=CC(C3=CC=CC(CN)=C3)=C1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (268.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1510 mL	10.7552 mL	21.5105 mL	107.5523 mL
5 mM	0.4302 mL	2.1510 mL	4.3021 mL	21.5105 mL
10 mM	0.2151 mL	1.0755 mL	2.1510 mL	10.7552 mL
20 mM	0.1076 mL	0.5378 mL	1.0755 mL	5.3776 mL
50 mM	0.0430 mL	0.2151 mL	0.4302 mL	2.1510 mL
100 mM	0.0215 mL	0.1076 mL	0.2151 mL	1.0755 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ZK-824859 hydrochloride (2271122-53-1 free base)ZK824859 hydrochloride (2271122531 free base)ZK824859 hydrochloride (2271122 53 1 free base)ZK-824859 HydrochlorideZK824859 HydrochlorideZK 824859 Hydrochloridehuman uPAhuman tPAhuman plasmin2271122-53-1 free base2271122-53-1

Related Tags: buy ZK824859 hydrochloride (2271122-53-1 free base) | purchase ZK824859 hydrochloride (2271122-53-1 free base) | ZK824859 hydrochloride (2271122-53-1 free base) cost | order ZK824859 hydrochloride (2271122-53-1 free base) | ZK824859 hydrochloride (2271122-53-1 free base) chemical structure | ZK824859 hydrochloride (2271122-53-1 free base) in vitro | ZK824859 hydrochloride (2271122-53-1 free base) formula | ZK824859 hydrochloride (2271122-53-1 free base) molecular weight