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PROTAC Linker

PROTAC linker plays a vital role in efficient ubiquitination of the target protein and its ultimate degradation. To date, several kinds of linkers have been reported and applied in PROTAC ternary complexes formation, such as PEG linker, Alkyl linker, alkyne linkers, and click chemistry linker, etc.

  • Ac4ManNAz
    T14093361154-30-5In house
    Ac4ManNAz is an azido-containing metabolic glycoprotein labeling reagent. It can be used to selectively modify proteins, and it can be used in cell labeling, tracking and proteomic analysis;
    • $32
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    TargetMol | Inhibitor Hot
  • Boc-NH-PEG8-CH2CH2COOH
    T176831334169-93-5
    Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $29
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    TargetMol | Inhibitor Sale
  • Boc-NH-PEG8-CH2CH2NH2
    T176841052207-59-6
    Boc-NH-PEG8-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $29
    In Stock
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  • Boc-NH-O-C1-NHS ester
    T1765580366-85-4
    Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in PROTAC synthesis.
    • $29
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    TargetMol | Inhibitor Sale
  • Fmoc-NH-PEG10-acid
    T179642101563-45-3
    Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker. Fmoc-NH-PEG10-acid can be used in the synthesis of PROTACs.
    • $29
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    TargetMol | Inhibitor Sale
  • Boc-C16-COOH
    T9783843666-40-0
    Boc-C16-COOH is a alkyl-chain-based PROTAC linker. Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    • $40
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    TargetMol | Inhibitor Sale
  • Azido-PEG10-alcohol
    T14413877239-09-3
    Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1].
    • $29
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    TargetMol | Inhibitor Sale
  • Azido-PEG12-acid
    T174842152679-71-3
    Azido-PEG12-acid is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $41
    In Stock
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  • m-PEG16-alcohol
    T18151133604-58-7
    m-PEG16-alcohol is a PEG-based PROTAC linker. m-PEG16-alcohol can be used in the synthesis of PROTACs.
    • $29
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    TargetMol | Inhibitor Sale
  • Azido-PEG1-azide
    T1747624345-74-2
    Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $29
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    TargetMol | Inhibitor Sale
  • Hydroxy-PEG5-Boc
    T15534850090-09-4
    Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1].
    • $29
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    TargetMol | Inhibitor Sale
  • Boc-NH-PEG3-NHS ester
    T176772250216-93-2
    Boc-NH-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $64
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    TargetMol | Inhibitor Sale
  • 1,3-Dibromo-5,5-dimethylhydantoin
    T1732177-48-5
    1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.
    • $29
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  • m-PEG7-Br
    T18215104518-25-4
    m-PEG7-Br is a PEG-based PROTAC linker. m-PEG7-Br can be used in the synthesis of PROTACs.
    • $29
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    TargetMol | Inhibitor Sale
  • Amino-PEG4-Boc
    T14238581065-95-4
    Amino-PEG4-Boc is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1].
    • $29
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  • m-PEG9-SH
    T18229651042-84-1
    m-PEG9-SH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
    • $47
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  • Mal-PEG5-Boc
    T182952250216-91-0
    Mal-PEG5-Boc (Mal-PEG5-COOtBu) is a PEG-based PROTAC linker. Mal-PEG5-Boc can be used in the synthesis of PROTACs.
    • $50
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  • Hydroxy-PEG10-acid
    T180312375611-66-6
    Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].
    • $50
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  • Propargyl-PEG12-bromide
    T185662410937-34-5
    Propargyl-PEG12-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
    • $95
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  • Mal-amido-PEG7-acid
    T159602112731-42-5
    Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
    • $195
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    TargetMol | Inhibitor Sale
  • Amino-PEG7-acid
    T174402376111-92-9
    Amino-PEG7-acid is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $55
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  • Cbz-NH-PEG12-C2-acid
    T177191334177-88-6
    Cbz-NH-PEG12-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
    • $53
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  • Propargyl-PEG5-Ms
    T185881036204-62-2
    Propargyl-PEG5-Ms (Propargyl-PEG6-Ms) is a PEG-based PROTAC linker. Propargyl-PEG5-Ms can be used in the synthesis of PROTACs.
    • $92
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    TargetMol | Inhibitor Sale
  • DSPE-PEG-OH (MW 2000)
    T17854
    DSPE-PEG-OH (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.
    • $133
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  • Propargyl-PEG11-methane
    T185682250411-18-6
    Propargyl-PEG11-methane is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].
    • $56
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  • m-PEG11-Br
    T181251258596-39-2
    m-PEG11-Br is a PEG-based PROTAC linker. m-PEG11-Br can be used in the synthesis of PROTACs.
    • $50
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  • Aminooxy-PEG4-alcohol
    T14271106492-60-8
    Aminooxy-PEG4-alcohol is both a non-cleavable 4-unit PEG ADC linker and a PEG-based PROTAC linker.
    • $50
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  • Azido-PEG12-NHS ester
    T174862363756-50-5
    Azido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $37
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  • Bis-Tos-PEG7
    T1763669502-27-8
    Bis-Tos-PEG7 is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $30
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  • 2-Phthalimidehydroxy-acetic acid
    T17330134724-87-1
    2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.
    • $59
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  • Cbz-NH-PEG5-CH2COOH
    T177241449390-66-2
    Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $77
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  • Propargyl-PEG17-methane
    T185742169967-47-7
    Propargyl-PEG17-methane (MPEG16-Propyne) is a PEG-based PROTAC linker. Propargyl-PEG17-methane can be used in the synthesis of PROTACs.
    • $40
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  • m-PEG16-Br
    T181531238189-11-1
    m-PEG16-Br is a PEG-based PROTAC linker. m-PEG16-Br can be used in the synthesis of PROTACs.
    • $53
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  • Azide-PEG12-Tos
    T174651821464-56-5
    Azide-PEG12-Tos is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $38
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  • 2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide
    T17326529493-92-3
    2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide (2-3-4-6-tetra-o-acetyl-alpha-galactosylpyranosyl-bromide) is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.
    • $37
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    TargetMol | Inhibitor Sale
  • Azido-PEG11-alcohol
    T174822252392-53-1
    Azido-PEG11-alcohol is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $98
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  • Bromo-PEG1-C2-azide
    T176981144106-65-9
    Bromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $33
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  • Acid-C1-PEG5-Boc
    T173522304558-22-1
    Acid-C1-PEG5-Boc is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $39
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  • Azido-PEG9-azide
    T175221171122-72-7
    Azido-PEG9-azide is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $98
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  • Biotin-PEG6-Boc
    T175911352814-07-3
    Biotin-PEG6-Boc (Biotin-PEG6-t-butyl ester) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $51
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  • NH2-PEG6-C1-Boc
    T18494297162-50-6
    NH2-PEG6-C1-Boc (H2N-PEG6-CH2COOtBu) is a PEG-based PROTAC linker. NH2-PEG6-C1-Boc can be used in the synthesis of PROTACs.
    • $50
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  • Amino-PEG14-alcohol
    T1741334214-89-6
    Amino-PEG14-alcohol (H2N-PEG14-OH) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $47
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  • Boc-NH-PEG7-Tos
    T176821292268-14-4
    Boc-NH-PEG7-Tos (t-Boc-N-Amido-PEG7-Tos) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
    • $31
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  • Azido-PEG4-azide
    T39268182760-73-2
    Azido-PEG4-azide is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
    • $50
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  • m-PEG7-4-nitrophenyl carbonate
    T15919678150-56-6
    m-PEG7-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1].
    • $65
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  • TGN-020
    T510251987-99-6
    TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.
    • $47
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    TargetMol | Citations Cited
  • Boc-NH-PEG3-CH2COOH
    T14741462100-06-7
    Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in PROTAC synthesis[1].
    • $83
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    TargetMol | Inhibitor Sale
  • Hydroxy-PEG4-(CH2)2-Boc
    T15529518044-32-1
    Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-(CH2)2-Boc can also be used in the synthesis of PROTAC.
    • $29
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  • Fmoc-Lys-OH hydrochloride
    T41312139262-23-0
    Fmoc-Lys-OH hydrochloride is a alkyl-chain-based PROTAC linker. Fmoc-Lys-OH hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    • $29
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  • N-Boc-4-pentyne-1-amine
    T18391151978-50-6
    N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound utilized in the synthesis of PROTAC MG-277[1].
    • $50
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