Shopping Cart

Your shopping cart is currently empty

SB 699551 dihydrochloride

Name: SB 699551 dihydrochloride
Brand: TargetMol
SKU: T23325
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T23325Cas No. 864741-95-7

SB 699551 dihydrochloride is a 5-ht5a receptor antagonist.

SB 699551 dihydrochloride

Copy Product Info

🥰Excellent

Purity: 99.83%

Catalog No. T23325Cas No. 864741-95-7

SB 699551 dihydrochloride is a 5-ht5a receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$189	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$472	In Stock	In Stock
100 mg	$648	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

SB 699551 dihydrochloride AI Summary

SB 699551 dihydrochloride exhibits a broad range of bioactivities, including a binding affinity towards the human serotonin transporter (Ki of 25.12 nM) and stimulation of [35S]GTP-gamma-S binding to the 5-Hydroxytryptamine receptor 5A with a pKb of 8.0. In guinea pigs, it shows varying levels of bioavailability, peak blood concentration, half-life, blood clearance, and volume of distribution depending on administration route and dosage. The compound also demonstrates inhibitory effects on cell growth in HEK293T, U2OS, and human fibroblast cell lines, suggesting it can suppress cell proliferation or induce cell death. Additionally, thermal shift assays indicate that SB 699551 dihydrochloride impacts the stability of protein domains, as reflected by changes in melting temperatures. Notably, the compound influences GPCR signaling by inhibiting beta-arrestin recruitment across a range of targets, including FPR2, GLP1R, and CX3CR1, among others, showing strong inhibitory effects on these receptors..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SB 699551 dihydrochloride is a 5-ht5a receptor antagonist.
Targets&IC50	5-HT5A receptor:8.3 (pKi)

Chemical Properties

Molecular Weight	584.66
Formula	C₃₄H₄₇Cl₂N₃O
Cas No.	864741-95-7
Smiles	Cl.Cl.CN(C)CCN(Cc1ccc(cc1)-c1ccc(CNCCc2ccccc2)cc1)C(=O)CCC1CCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (111.18 mM), Sonication is recommended.

Ethanol: < 5.85 mg/mL, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7104 mL	8.5520 mL	17.1040 mL	85.5198 mL
5 mM	0.3421 mL	1.7104 mL	3.4208 mL	17.1040 mL
10 mM	0.1710 mL	0.8552 mL	1.7104 mL	8.5520 mL
20 mM	0.0855 mL	0.4276 mL	0.8552 mL	4.2760 mL
50 mM	0.0342 mL	0.1710 mL	0.3421 mL	1.7104 mL
100 mM	0.0171 mL	0.0855 mL	0.1710 mL	0.8552 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc