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NEDD8 Protein, Human, Recombinant (His & SUMO)
(Synonyms: Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8) Copy Product InfoSynonyms: Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8
Catalog No. TMPJ-01133 Copy Product Info
Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. NEDD8 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 24 KDa and the accession number is Q15843.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 μg | $30 | 35 days | 35 days | |
| 20 μg | $38 | 35 days | 35 days | |
| 50 μg | $53 | 35 days | 35 days | |
| 100 μg | $87 | 35 days | 35 days | |
| 200 μg | $148 | 35 days | 35 days | |
| 500 μg | $310 | 35 days | 35 days | |
| 1 mg | $495 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:Greater than 95% as determined by reducing SDS-PAGE.
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. NEDD8 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 24 KDa and the accession number is Q15843. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-6xHis, SUMO |
| Accession Number | Q15843 |
| Amino Acid | Met1-Gly76 |
| Construction | Met1-Gly76 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, 5% Trehalose, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Ubiquitin-like protein Nedd8, Neural precursor cell expressed developmentally down-regulated protein 8, Neddylin, NEDD8 |
| Research Background |
| Molecular Weight | 24 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: NEDD8 Protein, Human, Recombinant (His & SUMO) chemical structure | NEDD8 Protein, Human, Recombinant (His & SUMO) molecular weight
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